Results 131 to 140 of about 402,753 (311)

ATF3 Deficiency Exacerbates Ageing‐Induced Atherosclerosis and Clinical Intervention Strategy

open access: yesAdvanced Science, EarlyView.
Targeting ATF3 with terazosin to against VSMC Senescence and atherosclerosis. TZ reduces the binding affinity of YTHDF2 to Atf3 mRNA, while enhancing mRNA stability. ATF3 promotes Atg7 transcription, enhancing autophagy. ATG7 binds to ATF3 in the cytoplasm, facilitating ATF3 translocation to the nucleus and establishing positive feedback. By modulating
Hao Nie   +11 more
wiley   +1 more source

Correlation Between Serum Vitamin E and HOMA-IR in Patients with T2DM

open access: yesDiabetes, Metabolic Syndrome and Obesity
Jing Zhang,1,2 Yilin Hou,1 Zhaozi Zhang,1 Yihe Shi,1 Zhimin Wang,1 Guangyao Song1,2 1Department of Internal Medicine, Graduate School of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Endocrinology, Hebei ...
Zhang J   +5 more
doaj  

Mitochondrial Regulation of CD8⁺ T Cells: Mechanisms and Therapeutic Modulation

open access: yesAdvanced Science, EarlyView.
This article comprehensively explores the pivotal role of mitochondrial function in CD8⁺ T cell immunotherapy. It highlights how mitochondrial dynamics regulate T cell activation, differentiation, and persistence, and how mitochondrial dysfunction leads to immune exhaustion and impaired antitumor/antiviral responses.
Xu Chen   +7 more
wiley   +1 more source

A Human Engineered Heart Tissue‐Derived Lipotoxic Diabetic Cardiomyopathy Model Revealed Early Benefits of Empagliflozin

open access: yesAdvanced Science, EarlyView.
This study develops a human engineered heart tissue‐derived model of diabetic cardiomyopathy that accurately replicates the dynamic changes in the structural, contractile, and electrophysiological properties of the myocardium. Furthermore, this model is used to confirm the direct protective effects of empagliflozin on the heart through an SGLT2 off ...
Lin Cai   +9 more
wiley   +1 more source

Autism Spectrum Disorder and Dietary Intake of Vitamin E. [PDF]

open access: yesNeuropsychopharmacol Rep
Mobarakeh KA   +13 more
europepmc   +1 more source

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