Results 171 to 180 of about 512,688 (367)

A Human Engineered Heart Tissue‐Derived Lipotoxic Diabetic Cardiomyopathy Model Revealed Early Benefits of Empagliflozin

open access: yesAdvanced Science, EarlyView.
This study develops a human engineered heart tissue‐derived model of diabetic cardiomyopathy that accurately replicates the dynamic changes in the structural, contractile, and electrophysiological properties of the myocardium. Furthermore, this model is used to confirm the direct protective effects of empagliflozin on the heart through an SGLT2 off ...
Lin Cai   +9 more
wiley   +1 more source

Delayed Transplantation of Neural Stem Cells Improves Initial Graft Survival after Stroke

open access: yesAdvanced Science, EarlyView.
Delayed transplantation of human iPSC‐derived neural progenitor cells (NPCs) enhances graft survival, proliferation, and axonal sprouting after stroke. Using bioluminescence imaging and histology in a mouse model of stroke, it is shown that NPC delivery at 7 days post‐stroke is more effective than acute transplantation, highlighting the importance of ...
Rebecca Z Weber   +6 more
wiley   +1 more source

Efficacy of two vitamin E formulations in patients with abetalipoproteinemia and chylomicron retention disease

open access: yesJournal of Lipid Research, 2018
Abetalipoproteinemia (ABL) and chylomicron retention disease (CMRD) are extremely rare recessive forms of hypobetalipoproteinemia characterized by intestinal lipid malabsorption and severe vitamin E deficiency. Vitamin E is often supplemented in the form
Charlotte Cuerq   +17 more
doaj  

STUDIES IN VITAMIN E DEFICIENCY

open access: hybrid, 1955
Harris Rosenkrantz
openalex   +1 more source

Organocatalytic C─O Bond Cleavage and Asymmetric Transformations via [1,3]‐Sigmatropic Rearrangement

open access: yesAdvanced Science, EarlyView.
A direct asymmetric strategy for fulfilling the functional group transfer by aryl ether cleavage and migration is developed, representing the first Brønsted base‐catalyzed asymmetric [1,3]‐sigmatropic rearrangement reaction. The resulting chiral benzofuran products generated through this strategy exhibit significant 3D‐dimensionality and demonstrate ...
Lei Peng   +7 more
wiley   +1 more source

Vitamin E and neurodegeneration

open access: yesNeurobiology of Disease, 2015
Alpha-tocopherol (vitamin E) is a plant-derived antioxidant that is essential for human health. Studies with humans and with animal models of vitamin E deficiency established the critical roles of the vitamin in protecting the central nervous system, and
Lynn M. Ulatowski, Danny Manor
doaj  

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