Results 231 to 240 of about 512,688 (367)

Alzheimer's Association clinical practice guideline for the Diagnostic Evaluation, Testing, Counseling, and Disclosure of Suspected Alzheimer's Disease and Related Disorders (DETeCD‐ADRD): Executive summary of recommendations for primary care

Alzheimer's &Dementia, EarlyView.
Abstract US clinical practice guidelines for the diagnostic evaluation of cognitive impairment due to Alzheimer's disease (AD) or AD and related dementias (ADRD) are decades old and aimed at specialists. This evidence‐based guideline was developed to empower all—including primary care—clinicians to implement a structured approach for evaluating a ...
Alireza Atri, Bradford C. Dickerson, Carolyn Clevenger, Jason Karlawish, David Knopman, Pei‐Jung Lin, Mary Norman, Chiadi Onyike, Mary Sano, Susan Scanland, Maria Carrillo   +10 more
wiley   +1 more source

Light‐Triggered CRISPR/Cas12a for Genomic Editing and Tumor Regression

Angewandte Chemie, EarlyView.
A photo‐triggered CRISPR/Cas12a machinery for gene editing is introduced. The machinery is applied for endogenous DNA methyltransferase 1 (DNMT1) gene editing and for in vitro disruption of the hepatocyte growth factor (HGF) gene. The machinery is used for in vivo knockout and disruption of the HGF gene in HepG2 tumors, resulting in effective apoptosis
Hong Liu, Jiantong Dong, Renzhi Wu, Jun Dai, Xiaoding Lou, Fan Xia, Itamar Willner, Fujian Huang   +7 more
wiley   +2 more sources

The potential role of vitamin E in patients with glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis

, 2023
Omar Ahmed Abdelwahab, Khaled Akil, Ali Seif, Mahmoud Allam, Mohamed El-Sebaey Sherif, Mohamed N. Al‐Alfy   +5 more
openalex   +1 more source

Astaxanthin ameliorates benzalkonium chloride–induced dry eye disease through suppressing inflammation and oxidative stress via Keap1‐Nrf2/HO‐1 signaling pathways

Animal Models and Experimental Medicine, EarlyView.
The flowchart of this research. Abstract Background Dry eye disease (DED) predominantly results from elevated tear film osmolarity, which can not only cause ocular inconvenience but may lead to visual impairments, severely compromising patient well‐being and exerting substantial economic burdens as well.
Ziyu Liu, Yaqiong Li, Jiayu Bao, Siyuan Li, Ya Wen, Peng Zhang, Jun Feng, Yinghui Wang, Lei Tian, Ying Jie   +9 more
wiley   +1 more source

Early Intravenous Correction of Vitamin E Deficiency in Premature Infants

, 1985
Gary R. Gutcher, Philip M. Farrell
openalex   +1 more source

Combined vitamin C and E deficiency induces motor defects in gulo^−/−/SVCT2^+/−mice [PDF]

, 2013
Marquicia R. Pierce, Danielle L. DiAsio, Laurisa M. Rodrigues, Fiona E. Harrison, James M. May   +4 more
openalex   +1 more source

Longitudinal Metabolomics in Amyotrophic Lateral Sclerosis Implicates Impaired Lipid Metabolism

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by altered metabolome and energy homeostasis, manifesting with body mass index changes and hypermetabolism—both prognostic of disease progression and survival.
Kai Guo, Masha G. Savelieff, Dae‐Gyu Jang, Samuel J. Teener, Lili Zhao, Junguk Hur, Stephen A. Goutman, Eva L. Feldman   +7 more
wiley   +1 more source

A Hypoxia‐Triggered Bioreduction of Hydrophilic Type I Photosensitizer for Switchable In Vivo Photoacoustic Imaging and High‐Specificity Cancer Phototherapy

Angewandte Chemie, EarlyView.
A hydrophilic type I phototherapeutic agent (NanoPcN8O) was developed which selectively responded to hypoxic tumor microenvironments and switched on type I photodynamic and photothermal effects as well as a photoacoustic signal for activatable photoacoustic imaging and tumor phototherapy.
Yuan‐Yuan Zhao, Yihui Xu, Xiaojun Zhang, Zixuan Chen, Heejeong Kim, Xingshu Li, Juyoung Yoon   +6 more
wiley   +2 more sources

Subacute combined degeneration associated with vitamin E deficiency due to small bowel obstruction: A case report. [PDF]

Medicine (Baltimore), 2019
Jung JB, Kim Y, Oh K, Kim SA, Doh JH, Oh HJ, Seok JM.   +6 more
europepmc   +1 more source

Effects of vitamin E deficiency on the functions of splenic lymphocytes and alveolar macrophages.

, 1989
Satoru Moriguchi, Naomichi Kobayashi, Yasuo Kishino   +2 more
openalex   +2 more sources