Results 1 to 10 of about 285,981 (197)

Vitamin D(3) and methylenebisphosphonic acid in the correction of mineral metabolism disorders and bone remodeling associated with glucocorticoid-induced osteoporosis [PDF]

The Ukrainian Biochemical Journal, 2023
The study was aimed at evaluating therapeutic efficacy of vitamin D3 (VD3, 1000 IU/kg of b.w., 30 days) and sodium salt of methylenebisphosphonic acid (MBPA, 17 mg/kg of b.w., 30 days) monotherapies as well as their effect in combination in preventing ...
O. O. Lisakovska, I. O. Shymanskyi, V. M. Vasylevska, E. P. Pasichna, M. M. Veliky, S. V. Komisarenko   +5 more
doaj   +1 more source

Clock and riboswitch control of THIC in tandem are essential for appropriate gauging of TDP levels under light/dark cycles in Arabidopsis

iScience, 2023
Summary: Metabolic homeostasis is regulated by enzyme activities, but the importance of regulating their corresponding coenzyme levels is unexplored. The organic coenzyme thiamine diphosphate (TDP) is suggested to be supplied as needed and controlled by ...
Zeenat Noordally, Lara Land, Celso Trichtinger, Ivan Dalvit, Mireille de Meyer, Kai Wang, Teresa B. Fitzpatrick   +6 more
doaj   +1 more source

Brain vitamin D3-auto/paracrine system in relation to structural, neurophysiological, and behavioral disturbances associated with glucocorticoid-induced neurotoxicity

Frontiers in Cellular Neuroscience, 2023
IntroductionVitamin D3 (VD3) is a potent para/autocrine regulator and neurosteroid that can strongly influence nerve cell function and counteract the negative effects of glucocorticoid (GC) therapy.
Olha Lisakovska, Dmytro Labudzynskyi, Anna Khomenko, Dmytro Isaev, Alina Savotchenko, Ludmila Kasatkina, Serhii Savosko, Mykola Veliky, Ihor Shymanskyi   +8 more
doaj   +1 more source

How Aging and Oxidative Stress Influence the Cytopathic and Inflammatory Effects of SARS-CoV-2 Infection: The Role of Cellular Glutathione and Cysteine Metabolism

Antioxidants, 2022
SARS-CoV-2 infection can cause a severe respiratory distress syndrome with inflammatory and thrombotic complications, the severity of which increases with patients’ age and presence of comorbidity. The reasons for an age-dependent increase in the risk of
Francesco Galli, Giada Marcantonini, Daniela Giustarini, Maria Cristina Albertini, Anna Migni, Linda Zatini, Antimo Gioiello, Ranieri Rossi, Desirée Bartolini   +8 more
doaj   +1 more source

The mortality effects of disregarding the strategy to save doses of measles vaccine: a cluster-randomised trial in Guinea-Bissau

BMJ Global Health, 2021
Introduction Measles vaccine (MV) may improve health beyond measles protection. To avoid wastage from multi-dose vials, children in Guinea-Bissau are only measles vaccinated when aged 9–11 months and when six or more children are present.
Peter Aaby, Ane Bærent Fisker, Amabelia Rodrigues, Christine Stabell Benn, Stine Byberg   +4 more
doaj   +1 more source

Effect of Propionic Acid on Diabetes-Induced Impairment of Unfolded Protein Response Signaling and Astrocyte/Microglia Crosstalk in Rat Ventromedial Nucleus of the Hypothalamus

Neural Plasticity, 2022
Background. The aim was to investigate the influence of propionic acid (PA) on the endoplasmic reticulum (ER), unfolded protein response (UPR) state, and astrocyte/microglia markers in rat ventromedial hypothalamus (VMH) after type 2 diabetes mellitus ...
Larysa V. Natrus, Yulia S. Osadchuk, Olha O. Lisakovska, Dmytro O. Labudzinskyi, Yulia G. Klys, Yuri B. Chaikovsky   +5 more
doaj   +1 more source

Natural Cryoprotective and Cytoprotective Agents in Cryopreservation: A Focus on Melatonin

Molecules, 2022
Cryoprotective and cytoprotective agents (Cytoprotective Agents) are fundamental components of the cryopreservation process. This review presents the essentials of the cryopreservation process by examining its drawbacks and the role of cytoprotective ...
Giada Marcantonini, Desirée Bartolini, Linda Zatini, Stefania Costa, Massimiliano Passerini, Mario Rende, Giovanni Luca, Giuseppe Basta, Giuseppe Murdolo, Riccardo Calafiore, Francesco Galli   +10 more
doaj   +1 more source

Vitamin D Auto-/Paracrine System Is Involved in Modulation of Glucocorticoid-Induced Changes in Angiogenesis/Bone Remodeling Coupling

International Journal of Endocrinology, 2020
Osteoporosis is a devastating side effect of chronic glucocorticoid (GC) treatment. Despite the crucial role of vitamin D (VD) in bone homeostasis, the precise molecular mechanisms of its action on GC-induced disturbances of bone remodeling remain ...
Olha Lisakovska, Ihor Shymanskyi, Dmytro Labudzynskyi, Anna Mazanova, Mykola Veliky   +4 more
doaj   +1 more source

Wheat germ oil vitamin E cytoprotective effect and its nutrigenomics signature in human hepatocyte lipotoxicity

Heliyon, 2022
Wheat germ oil (WGO) is rich in α-tocopherol (vitamin E, VE), a vitamin that has long been suggested to exert hepatoprotective effects. In this study, this function of WGO-VE and its transcriptomics fingerprint were investigated in comparison with RRR−α ...
Desirée Bartolini, Rita Marinelli, Anna Maria Stabile, Tiziana Frammartino, Angela Guerrini, Stefano Garetto, Jacopo Lucci, Anna Migni, Linda Zatini, Giada Marcantonini, Mario Rende, Francesco Galli   +11 more
doaj   +1 more source

Is early measles vaccination associated with stronger survival benefits than later measles vaccination?

BMC Public Health, 2018
Background Measles vaccine (MV) may protect against non-measles mortality. We tested whether survival depended on age of measles vaccination. Methods Bandim Health Project follows children under 5 years of age through a Health and Demographic ...
Jesper Sloth Hansen, Sanne Marie Thysen, Amabelia Rodrigues, Cesario Martins, Ane Bærent Fisker   +4 more
doaj   +1 more source