Long Term High‐Salt Diet Induces Cognitive Impairments via Down‐Regulating SHANK1
Advanced Science, EarlyView.The study identifies a novel mechanistic link between long‐term HS diet and cognitive impairment, wherein PKA/CREB axis inactivation leads to SHANK1 reduction, synaptic damage, and cognitive deficits. Abstract High‐salt (HS) diet is an established risk factor for cognitive impairment, but the underlying mechanisms remain unclear.
Cuiping Guo +10 more
wiley +1 more source
Results of Three Years' Experience with Microbiological Assay of Vitamin B12 in Serum [PDF]
, 1958 G. H. Spray, L. J. Witts
openalex +1 more source
ATF3 Deficiency Exacerbates Ageing‐Induced Atherosclerosis and Clinical Intervention Strategy
Advanced Science, EarlyView.Targeting ATF3 with terazosin to against VSMC Senescence and atherosclerosis. TZ reduces the binding affinity of YTHDF2 to Atf3 mRNA, while enhancing mRNA stability. ATF3 promotes Atg7 transcription, enhancing autophagy. ATG7 binds to ATF3 in the cytoplasm, facilitating ATF3 translocation to the nucleus and establishing positive feedback. By modulating
Hao Nie +11 more
wiley +1 more source
Correlation between vitamin A, D, E, and K levels in children with allergic rhinitis: a propensity-matched analysis. [PDF]
BMC PediatrLuo H, Wang X, Kong H, Wang J, Zhou Q.
europepmc +1 more source
PROPERTIES OF THE FILTRATE FACTOR OF THE VITAMIN B2 COMPLEX, WITH EVIDENCE FOR ITS MULTIPLE NATURE
, 1940 Ali Mohammad +3 more
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The microbiological assay of the vitamin-B complex and amino acids [PDF]
, 1953 William D. Rosenfeld
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Mitochondrial Regulation of CD8⁺ T Cells: Mechanisms and Therapeutic Modulation
Advanced Science, EarlyView.This article comprehensively explores the pivotal role of mitochondrial function in CD8⁺ T cell immunotherapy. It highlights how mitochondrial dynamics regulate T cell activation, differentiation, and persistence, and how mitochondrial dysfunction leads to immune exhaustion and impaired antitumor/antiviral responses.
Xu Chen +7 more
wiley +1 more source
Invertebrates of Siberia, a Potential Source of Animal Protein for Innovative Food and Feed Production: Biomass Nutrient Composition Change in the Earthworm <i>Eisenia fetida</i> (Savigny, 1826) and the House Cricket <i>Acheta domesticus</i> (Linnaeus, 1758). [PDF]
InsectsTshernyshev SE +9 more
europepmc +1 more source
Advanced Science, EarlyView.This study develops a human engineered heart tissue‐derived model of diabetic cardiomyopathy that accurately replicates the dynamic changes in the structural, contractile, and electrophysiological properties of the myocardium. Furthermore, this model is used to confirm the direct protective effects of empagliflozin on the heart through an SGLT2 off ...
Lin Cai +9 more
wiley +1 more source