Results 51 to 60 of about 377,437 (162)

The dark sides of the GPCR tree ‐ research progress on understudied GPCRs

British Journal of Pharmacology, Volume 182, Issue 14, Page 3109-3134, July 2025.
Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf, Laura J. Humphrys, Sandra Berndt, Antonella Di Pizio, Juliane Lehmann, Ines Liebscher, Alessandro Nicoli, Masha Y. Niv, Lior Peri, Hannes Schihada, Gunnar Schulte   +10 more
wiley   +1 more source

Proliferative vitreoretinopathy

Zdravniški Vestnik, 2005
Background: Proliferative vitreoretinopathy (PVR) is a disease characterized by formation of membranes on both surfaces of the retina and vitreous base. PVR is a wound healing response which is inadequate and uncontrolled in the eye. Identifying the risk
Mojca Globočnik-Petrovič, Andrejka Preskar   +1 more
doaj  

Annexin A2 promotes proliferative vitreoretinopathy in response to a macrophage inflammatory signal in mice

Nature Communications
Proliferative vitreoretinopathy is a vision-threatening response to penetrating ocular injury, for which there is no satisfactory treatment. In this disorder, retinal pigment epithelial cells, abandon their attachment to Bruch’s membrane on the scleral ...
Min Luo, Dena Almeida, Valentina Dallacasagrande, Nadia Hedhli, Mrinali Gupta, Donald J. D’Amico, Szilárd Kiss, Katherine A. Hajjar   +7 more
doaj   +1 more source

Phenotypic Expansion of Knobloch Syndrome Type 2 in an Individual With a De Novo PAK2 Variant

American Journal of Medical Genetics Part A, Volume 197, Issue 6, June 2025.
ABSTRACT P21‐activated kinase 2 (PAK2) is a serine/threonine kinase essential for a variety of cellular processes including signal transduction, cellular survival, proliferation, and migration. A recent report proposed monoallelic PAK2 variants cause Knobloch syndrome type 2 (KNO2)—a developmental disorder primarily characterized by ocular anomalies ...
Elizabeth A. Werren, Louisa Kalsner, Jessica M. Ewald, Michael Peracchio, Cameron King, Purva Vats, Peter A. Audano, Peter N. Robinson, Mark D. Adams, Melissa A. Kelly, Adam P. Matson   +10 more
wiley   +1 more source

Intravitreal injection of bevacizumab in primary vitrectomy to decrease the rate of retinal redetachment: A randomized pilot study

Journal of Ophthalmic & Vision Research, 2016
Purpose: To evaluate the effect of intravitreal bevacizumab (IVB) as a surgical adjunct in prevention of proliferative vitreoretinopathy (PVR) after retinal detachment surgery. Methods: In this controlled, randomized pilot study, 27 patients with primary
Adib Tousi, Hossein Hasanpour, Masoud Soheilian   +2 more
doaj   +1 more source

A Retrospective Clinical Study of the Etiology and Post-operative Visual Outcome of Rhegmatogenous Retinal Detachment [PDF]

Journal of Clinical and Diagnostic Research, 2014
Aim: To study the etiology of rhegmatogenous retinal detachment and visual outcome after retinal detachment surgery. Materials and methods: Retrospective study conducted at the tertiary eye care hospital over a period of one year.
Achyut N Pandey, Anil Kakde
doaj   +1 more source

The effect of axial length on pseudophakic retinal detachment

Acta Ophthalmologica, Volume 103, Issue 2, Page 146-151, March 2025.
Abstract Purpose The purpose of the study was to analyse the surgical management and outcome regarding axial length in the population affected by pseudophakic retinal detachment (PRD) 2015–2020. Method The patients included were from an observational cohort study of patients undergoing cataract surgery in the region of Skåne during 2015–2017. Data were
Joakim Thylefors, Rafi Sheikh, Gunnar Jakobsson   +2 more
wiley   +1 more source

Delayed presentation and increased prevalence of proliferative vitreoretinopathy for primary rhegmatogenous retinal detachments presenting during the COVID-19 pandemic lockdown

Eye, 2020
We read with interest your recent article ‘The impact of COVID policies on acute ophthalmology services– experiences from Moorfields Eye Hospital NHS Foundation Trust’ [1].
M. Awad, A. Poostchi, G. Orr, D. Kumudhan, A. Zaman, C. Wilde   +5 more
semanticscholar   +1 more source

Clinical and genetic characteristics and natural history of Finnish families with familial exudative vitreoretinopathy due to pathogenic FZD4 variants

Acta Ophthalmologica, Volume 103, Issue 2, Page 152-161, March 2025.
Abstract Purpose To report clinical and genetic characteristics of familial exudative vitreoretinopathy (FEVR) in the Finnish population. Methods Detailed clinical and genetic data of 35 individuals with heterozygous pathogenic variants in FZD4 were gathered and analysed.
Laura Lähteenoja, Tapani Palosaari, Timo Tiirikka, Maria Haanpää, Jukka Moilanen, Aura Falck, Elisa Rahikkala   +6 more
wiley   +1 more source

A Review of Innovations in Rhegmatogenous Retinal Detachment Surgical Techniques

Journal of Ophthalmology, 2017
Rhegmatogenous retinal detachment (RRD) requires surgical intervention for its repair. There are variable techniques used for this purpose, and they are all being continuously refined.
Achia Nemet, Ala Moshiri, Glenn Yiu, Anat Loewenstein, Elad Moisseiev   +4 more
doaj   +1 more source