Results 121 to 130 of about 39,767 (221)
ABSTRACT While the efficacy of canakinumab, an anti‐interleukin‐1β monoclonal antibody, is well‐established, its safety profile, particularly across different age groups, remains inadequately explored. Using the FDA Adverse Event Reporting System (FAERS) database, this study evaluated postmarketing safety by analyzing adverse event (AE) reports from ...
Youyang Wang +3 more
wiley +1 more source
The molecular mechanisms of RORA targeting PRNP activate oxidative injury‐induced cellular senescence and apoptosis of lens epithelial cells. Current research confirms that the transcription factor RORA targets PRNP, exacerbating cellular senescence and apoptosis of LECs (Figure 7).
Yue Zou +11 more
wiley +1 more source
Carbonic Anhydrase in the Vitreous Body [PDF]
openaire +2 more sources
Axial length, myopia progression, and myopic maculopathy in Stickler syndrome
Abstract Purpose We lack knowledge on the potentially progressive nature of and the prevalence of complications to myopia as a characteristic trait of Stickler syndrome. Methods This cross‐sectional study combines ophthalmic examination and medical record data on Danish patients with genetically confirmed Stickler syndrome type 1 (COL2A1) and type 2 ...
Kirstine B. Boysen +4 more
wiley +1 more source
This study expands the clinical spectrum of SMARCA4 by describing a novel phenotype in three unrelated individuals with truncating variants. Distinct from Coffin–Siris syndrome and rhabdoid tumor predisposition, this new association is characterized by ocular malformations, specifically microphthalmia and coloboma.
Bertrand Chesneau +7 more
wiley +1 more source
Neurological disorders are hard to treat. Stem cell‐derived neural organoids enable research, and their transplantation aids CNS therapy, with this article reviewing relevant advances, challenges and prospects. ABSTRACT Neurological disorders are often devastating and notoriously difficult to repair, creating an urgent need for novel research models ...
Yutong Wang +8 more
wiley +1 more source
ABSTRACT Light can be used to deter bycatch from fishing nets, but few studies have aimed to quantify how species view and respond to light. Here, we used visual models to predict how target (plaice Pleuronectes platessa) and bycatch (small‐spotted catshark Scyliorhinus canicular and undersized skates, Raja spp) species, captured in mixed demersal ...
Jasmine Somerville +2 more
wiley +1 more source
Combined anterior corneal elastic sublaminectomy, conjunctival flap, and prosthetic eyepiece for ocular atrophy following foldable capsular vitreous body implantation in severe trauma. [PDF]
Wu LD +9 more
europepmc +1 more source
ABSTRACT Multicomponent mesoporous bioactive glass nanoparticles (MMBGs) were engineered to enable coupled ionic and molecular release for controlled ionic and molecular release applications. The nanoparticles (70SiO2–20CaO–4B2O3–3ZnO–3CuO, mol%) were synthesized via a microemulsion‐assisted sol–gel route, yielding spherical particles (∼560 nm) with ...
Gabriela Colares Ali Ganem +4 more
wiley +1 more source

