Results 121 to 130 of about 39,767 (221)

Age‐Dependent Differences in Canakinumab Safety: A Comprehensive Pharmacovigilance Analysis Using the FAERS Database

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT While the efficacy of canakinumab, an anti‐interleukin‐1β monoclonal antibody, is well‐established, its safety profile, particularly across different age groups, remains inadequately explored. Using the FDA Adverse Event Reporting System (FAERS) database, this study evaluated postmarketing safety by analyzing adverse event (AE) reports from ...
Youyang Wang   +3 more
wiley   +1 more source

RORA Targeting PRNP Modulates Age‐Related Cataract via Activation Oxidative Injury‐Induced Cellular Senescence and Apoptosis of Lens Epithelial Cells

open access: yesAging Cell, Volume 25, Issue 6, June 2026.
The molecular mechanisms of RORA targeting PRNP activate oxidative injury‐induced cellular senescence and apoptosis of lens epithelial cells. Current research confirms that the transcription factor RORA targets PRNP, exacerbating cellular senescence and apoptosis of LECs (Figure 7).
Yue Zou   +11 more
wiley   +1 more source

Axial length, myopia progression, and myopic maculopathy in Stickler syndrome

open access: yesActa Ophthalmologica, Volume 104, Issue 4, Page 423-430, June 2026.
Abstract Purpose We lack knowledge on the potentially progressive nature of and the prevalence of complications to myopia as a characteristic trait of Stickler syndrome. Methods This cross‐sectional study combines ophthalmic examination and medical record data on Danish patients with genetically confirmed Stickler syndrome type 1 (COL2A1) and type 2 ...
Kirstine B. Boysen   +4 more
wiley   +1 more source

Expanding the Phenotypic Spectrum Associated With Loss‐of‐Function SMARCA4 Variants to Eye Developmental Anomalies

open access: yesClinical Genetics, Volume 109, Issue 6, Page 1064-1069, June 2026.
This study expands the clinical spectrum of SMARCA4 by describing a novel phenotype in three unrelated individuals with truncating variants. Distinct from Coffin–Siris syndrome and rhabdoid tumor predisposition, this new association is characterized by ocular malformations, specifically microphthalmia and coloboma.
Bertrand Chesneau   +7 more
wiley   +1 more source

Next‐Generation Strategies for Neural Repair and Regeneration: Neural Organoid Transplantation in the CNS

open access: yesCell Proliferation, Volume 59, Issue 6, June 2026.
Neurological disorders are hard to treat. Stem cell‐derived neural organoids enable research, and their transplantation aids CNS therapy, with this article reviewing relevant advances, challenges and prospects. ABSTRACT Neurological disorders are often devastating and notoriously difficult to repair, creating an urgent need for novel research models ...
Yutong Wang   +8 more
wiley   +1 more source

Vitreous body

open access: yes, 2018
Clinton Nash   +2 more
openaire   +1 more source

Visual Modelling to Predict Behavioural Responses of Catsharks, Skates, and Plaice to Artificial Light for Use in Bycatch Reduction

open access: yesFisheries Management and Ecology, Volume 33, Issue 3, Page 463-478, June 2026.
ABSTRACT Light can be used to deter bycatch from fishing nets, but few studies have aimed to quantify how species view and respond to light. Here, we used visual models to predict how target (plaice Pleuronectes platessa) and bycatch (small‐spotted catshark Scyliorhinus canicular and undersized skates, Raja spp) species, captured in mixed demersal ...
Jasmine Somerville   +2 more
wiley   +1 more source

Coupled Ionic‐Molecular Release Governed by Dissolution and Diffusion in Multicomponent Bioactive Glass Nanoparticles

open access: yesInternational Journal of Applied Ceramic Technology, Volume 23, Issue 3, June 2026.
ABSTRACT Multicomponent mesoporous bioactive glass nanoparticles (MMBGs) were engineered to enable coupled ionic and molecular release for controlled ionic and molecular release applications. The nanoparticles (70SiO2–20CaO–4B2O3–3ZnO–3CuO, mol%) were synthesized via a microemulsion‐assisted sol–gel route, yielding spherical particles (∼560 nm) with ...
Gabriela Colares Ali Ganem   +4 more
wiley   +1 more source

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