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β-VLDL induced VLDL-R’s up-regulation via PKC-ERK1/2 signal pathway
Current Medical Science, 2004To explore the intracellular signal pathways for beta-VLDL induced very low density lipoprotein receptor (VLDL-R) transcription up-regulation and their effects on lipid accumulation in macrophages, Western Blot was used to examine phosphorylated ERK1/2 protein and regulated effects by different singal kinase inhibitants.
Zhiguo, Liu +6 more
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Role of VLDL receptor in atherogenesis
Current Opinion in Lipidology, 2021Purpose of review My group previously discovered and characterized the rabbit and human VLDL receptors. For more than 30 years, I have focused on research regarding the functions of VLDL receptors in the fields of lipoprotein metabolism and atherogenesis.
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Nihon rinsho. Japanese journal of clinical medicine, 1995
The LDL receptor was discovered by Goldstein and Brown in 1974. This discovery has led to dramatic progress toward understanding the mechanisms of cholesterol homeostasis. Recently we have found a second lipoprotein receptor that specifically binds apoE-containing lipoproteins.
J, Sakai, T, Yamamoto
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The LDL receptor was discovered by Goldstein and Brown in 1974. This discovery has led to dramatic progress toward understanding the mechanisms of cholesterol homeostasis. Recently we have found a second lipoprotein receptor that specifically binds apoE-containing lipoproteins.
J, Sakai, T, Yamamoto
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Hyperinsulinemia and VLDL Kinetics
1993The most frequent lipoprotein abnormality in diabetes mellitus is hypertriglyceridemia. The frequency of hypercholesterolemia is not very different from that found in the nondiabetic population.1,2 In those diabetic individuals who are grossly insulin deficient, the hypertriglyceridemia is due to an accumulation of chylomicrons, the primary ...
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Metabolism of n-VLDL and β-VLDL in peritoneal macrophages from diabetic mice
Journal of Tongji Medical University, 1989Peritoneal macrophages were harvested from both healthy mice and mice with diabetes induced by intravenous injection of streptozotocin. After incubation with normal plasma very low density lipoprotein (n-VLDL) from swine for 24 h, the content of triglyceride (TG) in macrophages from diabetic mice was higher than that in the controls, and it was the ...
G, Gheng +5 more
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Metabolism of VLDL and LDL subclasses
Current Opinion in Lipidology, 1994The recognition of lipoprotein heterogeneity has given new depth to our understanding of lipoprotein metabolism and the role of plasma triglyceride as a determinant of lipoprotein subclass distribution and potential atherogenicity. It has also provided insight into the relationship between exogenous and endogenous lipid transport pathways, the roles of
B A, Griffin, C J, Packard
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Estimation of VLDL cholesterol in hyperlipidemia
Clinica Chimica Acta, 1985Lipoprotein data from 10947 fasting blood samples drawn between 1968 and 1982 in the Molecular Disease Branch at the National Institutes of Health were used to test the generalizability of estimating very low density lipoprotein cholesterol (VLDL-C) from plasma triglyceride (TG).
P W, Wilson +6 more
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1977
Of the methods to measure VLDL triglyceride (TG) turnover in humans, the simplest is that utilizing 3H-glycerol. We showed that when simultaneous measurements were made with the radioglycerol method and the lipolytic rate method, a method which depends on different assumptions, similar turnover rates were obtained (Steiner and Murase, 1975). This paper
Georg Steiner, Dan Streja
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Of the methods to measure VLDL triglyceride (TG) turnover in humans, the simplest is that utilizing 3H-glycerol. We showed that when simultaneous measurements were made with the radioglycerol method and the lipolytic rate method, a method which depends on different assumptions, similar turnover rates were obtained (Steiner and Murase, 1975). This paper
Georg Steiner, Dan Streja
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