Results 61 to 70 of about 33,379 (263)

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Experimental Research and Numerical Simulation on Gas-Liquid Separation Performance at High Gas Void Fraction of Helically Coiled Tube Separator

International Journal of Chemical Engineering, 2014
The industrial removal process of the light hydrocarbon and water from wet natural gas can be simulated in laboratory with the independently designed helically coiled tube gas-liquid separator.
Yongxue Zhang, Chan Guo, Hucan Hou, Guomin Xue   +3 more
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Experimental investigation of the effect of liquid viscosity on slug flow in small diameter bubble column

EPJ Web of Conferences, 2012
The effect of liquid viscosity on slug flow in a 50 mm diameter bubble column was investigated experimentally using air-silicone oil as operating fluid with silicone oil of viscosities 5, 100, 1000 and 5000 mPa.s.
Azzopardi Barry John, Kajero Olumayowa Timothy, Abdulkareem Lokman   +2 more
doaj   +1 more source

Determination of Cluster Hydrodynamics in Bubbling Fluidized Beds by the EMMS Approach

Journal of Chemical and Petroleum Engineering, 2011
The local solid flow structure of gas-solid bubbling fluidized bed was investigated to identify and characterize the particle clusters. Extensive mathematical calculations were carried out using the energy-minimization multi-scale (EMMS) approach for ...
Farzaneh Moradgholi, Navid Mostoufi, Rahmat Sotudeh-Gharebagh   +2 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Development of a Model Foamy Viscous Fluid

Oil & Gas Science and Technology, 2013
The objective is to develop a model viscous foamy fluid, i.e. below the very wet limit, the rheological and stability properties of which can be tuned.
Vial C., Narchi I.
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Numerical Simulation of Inlet Void Fraction Affecting Oil-gas Two-phase Flow Characteristics in 90° Elbows [PDF]

Journal of Applied Fluid Mechanics
Air can have an adverse effect on the performance of an aero-engine lubrication system. A numerical analysis was conducted to explore the influence of inlet void fraction and pipe layout on the characteristics of oil-gas two-phase flow in a 90° elbow.
W. Sha, G. Leng, R. S. Xu, S. Li
doaj   +1 more source