Results 81 to 90 of about 207,619 (294)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Spatiotemporal Evolution of Gas in Transmission Fluid under Acoustic Cavitation Conditions

open access: yesApplied Sciences
The presence of gas in transmission fluid can disrupt the flow continuity, induce cavitation, and affect the transmission characteristics of the system.
Yongjin Wang   +7 more
doaj   +1 more source

Calculation Method of Phase Interfacial Parameter for Churn Flow and Annular Flow in Narrow Rectangular Channel

open access: yesYuanzineng kexue jishu, 2022
The void fraction and interfacial area concentration are important phase interfacial parameters in two-phase flow. Accurate acquisition of void fraction and interfacial area concentration under churn flow and annular flow in a narrow rectangular channel
CHENG Linhai;GU Haifeng;LIU Antai;YU Xiang;ZHANG Junyi
doaj  

An improved electrical-conductance sensor for void-fraction measurement in a horizontal pipe

open access: yesNuclear Engineering and Technology, 2015
The electrical-impedance method has been widely used for void-fraction measurement in two-phase flow due to its many favorable features. In the impedance method, the response characteristics of the electrical signal heavily depend upon flow pattern, as ...
Min Seok Ko   +5 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Numerical Study of the Steady-State Subchannel Test-Case with NEPTUNE_CFD for the OECD/NRC NUPEC PSBT Benchmark

open access: yesScience and Technology of Nuclear Installations, 2012
The multifield computational fluid dynamics (CFD) code NEPTUNE_CFD is applied to carry out a numerical study of the steady-state subchannel test-case of the OECD/NRC NUPEC PWR subchannel and bundle tests (PSBTs) international benchmark, focusing on the ...
C. Baudry   +5 more
doaj   +1 more source

Three dimensional analysis of temperature effect on control rod worth in TRR

open access: yesNuclear Engineering and Technology, 2018
In this paper, three-dimensional neutronic calculations were performed in order to calculate the dependency of CRW on the temperature of fuel and moderator and the moderator void.
Maedeh Yari   +3 more
doaj   +1 more source

Simultaneous capacitive probe and planar laser-induced fluorescence measurements in downwards gas-liquid annular flow [PDF]

open access: yes, 2017
Various experimental techniques are available to analyse two-phase flows. The measurement concept and the applicability can however vary greatly. Prime examples from the opposite spectrum are planar laser-induced measurements (PLIF) versus capacitive ...
An, Jae S   +4 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Experimental Research and Numerical Simulation on Gas-Liquid Separation Performance at High Gas Void Fraction of Helically Coiled Tube Separator

open access: yesInternational Journal of Chemical Engineering, 2014
The industrial removal process of the light hydrocarbon and water from wet natural gas can be simulated in laboratory with the independently designed helically coiled tube gas-liquid separator.
Yongxue Zhang   +3 more
doaj   +1 more source

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