Results 81 to 90 of about 208,904 (295)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Spatiotemporal Evolution of Gas in Transmission Fluid under Acoustic Cavitation Conditions

Applied Sciences
The presence of gas in transmission fluid can disrupt the flow continuity, induce cavitation, and affect the transmission characteristics of the system.
Yongjin Wang, Yihong Chen, Xiaolu Li, Cangsu Xu, Wenjian Wei, Jinhui Zhao, Jie Jin, Francis Oppong   +7 more
doaj   +1 more source

Calculation Method of Phase Interfacial Parameter for Churn Flow and Annular Flow in Narrow Rectangular Channel

Yuanzineng kexue jishu, 2022
The void fraction and interfacial area concentration are important phase interfacial parameters in two-phase flow. Accurate acquisition of void fraction and interfacial area concentration under churn flow and annular flow in a narrow rectangular channel
CHENG Linhai;GU Haifeng;LIU Antai;YU Xiang;ZHANG Junyi
doaj  

An improved electrical-conductance sensor for void-fraction measurement in a horizontal pipe

Nuclear Engineering and Technology, 2015
The electrical-impedance method has been widely used for void-fraction measurement in two-phase flow due to its many favorable features. In the impedance method, the response characteristics of the electrical signal heavily depend upon flow pattern, as ...
Min Seok Ko, Bo An Lee, Woo Youn Won, Yeon Gun Lee, Dong Wook Jerng, Sin Kim   +5 more
doaj   +1 more source

Eulerian-Lagrangian method for simulation of cloud cavitation [PDF]

, 2017
We present a coupled Eulerian-Lagrangian method to simulate cloud cavitation in a compressible liquid. The method is designed to capture the strong, volumetric oscillations of each bubble and the bubble-scattered acoustics.
Colonius, Tim, Maeda, Kazuki
core   +3 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Numerical Study of the Steady-State Subchannel Test-Case with NEPTUNE_CFD for the OECD/NRC NUPEC PSBT Benchmark

Science and Technology of Nuclear Installations, 2012
The multifield computational fluid dynamics (CFD) code NEPTUNE_CFD is applied to carry out a numerical study of the steady-state subchannel test-case of the OECD/NRC NUPEC PWR subchannel and bundle tests (PSBTs) international benchmark, focusing on the ...
C. Baudry, M. Guingo, A. Douce, J. Laviéville, S. Mimouni, M. Boucker   +5 more
doaj   +1 more source

Three dimensional analysis of temperature effect on control rod worth in TRR

Nuclear Engineering and Technology, 2018
In this paper, three-dimensional neutronic calculations were performed in order to calculate the dependency of CRW on the temperature of fuel and moderator and the moderator void.
Maedeh Yari, Ahmad Lashkari, S. Farhad Masoudi, Mirshahram Hosseinipanah   +3 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source