Results 41 to 50 of about 125,224 (248)

Unveiling the inhibitory effect of hydrogen-decorated voids and dislocation loops on the glide of edge dislocation in tungsten

open access: yesNuclear Fusion
Tungsten (W), as the most promising candidate for plasma-facing materials, will experience significant irradiation hardening in nuclear fusion environment, which is originated from the formation of displacement damages, such as voids and dislocation ...
Qing-Yuan Ren   +7 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

An Integrated and Hierarchical Geophysical Workflow for Subsurface Cavity Assessment in Legacy Mining Districts

open access: yesRemote Sensing
The presence of near-surface cavities poses a significant geohazard due to potential ground subsidence and structural collapse. To mitigate threats to urban stability, this study presents an integrated geophysical framework to locate and characterize ...
Javier Rey   +3 more
doaj   +1 more source

General solution and fundamental solution for two-dimensional problem in orthotropic thermoelastic media with voids [PDF]

open access: yesTheoretical and Applied Mechanics, 2014
The aim of the present paper is to study the fundamental solution in orthotropic thermoelastic media with voids. With this objective, firstly the two-dimensional general solution in orthotropic thermoelastic media with voids is derived.
Kumar Rajneesh, Chawla Vijay
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Investigation of Voids in the Apical Plug of MTA Using Cone-Beam Computed Tomography, Digital Radiography, and Analog Radiography [PDF]

open access: yesJournal of Dentistry
Background: Achieving a satisfactory apical seal in root canals with open apices can be challenging, with the risk of filling material extrusion into the apex.
Mahsa Eskandarinezhad   +5 more
doaj   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

open access: yesFEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual   +3 more
wiley   +1 more source

The Impact of Laser Irradiation on Thin ZrN Films Deposited by Pulsed DC Magnetron Sputtering

open access: yesNanomaterials
Transition metal nitrides have extensive applications, including magnetic storage devices, hardware resistance coatings, and low-temperature fuel cells.
Ameena Nazneen, Penghui Lei, Di Yun
doaj   +1 more source

Void Mediated Failure at the Extremes: Spallation in Magnesium and Aluminum

open access: yesMetals, 2022
This paper reviews the role of void nucleation, growth, and coalescence on the spall failure process in light metals. Based on the review of the open literature, the preponderance of evidence show that void nucleation, growth, and coalescence are ...
Cyril Labode Williams
doaj   +1 more source

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