Results 111 to 120 of about 927 (261)

Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor–Ligand Interactions

Advanced Science, EarlyView.
This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim, In Ah Kwon, Bo Seop Jeong, Hyo Seon Kim, Joo‐Hwan Park, Sung Jean Park, Sang‐Rae Lee, Youngki Lee, Dongwoo Khang   +8 more
wiley   +1 more source

Confinement‐Driven CO Spillover in CuAg@MSN Tandem Catalysts Boosts C2 Selectivity Toward Electrocatalytic CO2 Reduction

Advanced Science, EarlyView.
The CuAg@MSN catalyst developed in this study promotes C─C coupling by regulating the coverage of *CO intermediates through spatial confinement effects, significantly enhancing the selectivity of CO2 electroreduction for C2 product formation. ABSTRACT Tandem catalysts represent a promising paradigm for synergistic electrochemical CO2 reduction (CO2RR ...
Jiaying Zhang, Junjie Huang, Siying Zhang, Yanjia Cui, Chao Kong, Zijian Peng, Huihui Jiang, Sirui Deng, Zhuoyao Chen, Caili Yang, Ketong He, Zhen Li, Yibing Song, Gongwei Wang, Lin Zhuang   +14 more
wiley   +1 more source

Siderite Concretions in Svalbard Lake Sediments Capture 7,000 Years of Extreme Arctic Cold Season Climate Change

Geophysical Research Letters
The Arctic warms faster than anywhere else on Earth, and paleoclimate data are key to placing this amplified response in a long‐term context. But most past temperature proxies record growing season conditions, when their biological signal carriers are ...
Willem G. M. van derBilt, Barnabás Csiszár, Marie Bulínová, Leif‐Erik R. Pedersen, Alexandra Rouillard, Ingunn H. Thorseth, Torgeir O. Røthe, Mateusz C. Strzelecki, Anders Schomacker   +8 more
doaj   +1 more source

Micro‐Galvanic Coupling Programs the Therapeutic Zinc Ion Window to Reconfigure Immune Cascades for Pro‐Regenerative Bone Healing

Advanced Science, EarlyView.
This study utilized alloy micro‐galvanic coupling design to regulate the release of essential elements, thereby programming immune responses and promoting regeneration. The sacrificial anodic process of Zn‐0.8Mg reduced Zn2+ release compared to the “large cathode‐small anode” coupling of Zn‐0.8Fe.
Chaoyang Sun, Bo Jia, Jiahui Shi, Shuang Li, Guo Bao, Dong Bian, Kai Chen, Junlong Tan, Xuenan Gu, Yan Guan, Yu Qin, Xinhua Qu, Xiaogang Wang, Yufeng Zheng, Hongtao Yang   +14 more
wiley   +1 more source

A Biomimetic Dual‐Targeting Nano‐APA‐Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy

Advanced Science, EarlyView.
This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao, Bin Gu, Hui Zhao, Kun Tan, Qin Zhao, Zhengjun Shang   +5 more
wiley   +1 more source

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source

Interfacial Water Coordination on Ruthenium Oxide Nanoparticles Confined Within Covalent Organic Framework and Its Effect on Electrochemical Nitrate Reduction

Advanced Science, EarlyView.
We demonstrate how oxygen‐deficient ruthenium oxide (RuOx) nanoparticles confined within covalent organic framework achieve highly efficient nitrate‐to‐ammonia conversion. Strong interaction between RuOx nanoparticles and COF results in modified interfacial hydrogen‐bond water network and adsorption of nitrogenous intermediates.
Yun Li, Xin Zhao, Arsenii S. Portniagin, Yuxuan Wu, Desui Chen, Haochen Liu, Andrey L. Rogach   +6 more
wiley   +1 more source

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, EarlyView.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

Biointegrated Multilayer Stretchable OLED Platform With Strain‐Decoupled Architecture for Durable Phototherapeutic Applications

Advanced Science, EarlyView.
A multilayer stretchable organic light‐emitting diode (SOLED) patch enables conformal, high‐fill‐factor phototherapeutic illumination through vertically decoupled electrodes and robust encapsulation. The textile‐based SOLED platform delivers stable skin‐contact red light for wearable phototherapy and 5‐aminolevulinic acid (ALA)‐mediated photodynamic ...
Young Hyun Son, Myeongheon Lee, Jun‐Yeop Song, Hyo‐Jung Kwon, Kyung Cheol Choi, Jeong Hyun Kwon   +5 more
wiley   +1 more source

Oceanic and volcanic heat converge in a subglacial channel of the Kamb Ice Stream in West Antarctica

Communications Earth & Environment
Melting from oceanic heat and basal lubrication from subglacial freshwater are fundamental elements of the West Antarctic Ice Sheet mass balance that are poorly constrained. The ice streams feeding the Ross Ice Shelf grounding line periodically start and
Peter Washam, Britney E. Schmidt, Brice Loose, Huw J. Horgan, Craig L. Stewart, Craig L. Stevens, Justin D. Lawrence, Christina L. Hulbe, Andrew D. Mullen, Enrica S. Quartini, Benjamin Hurwitz   +10 more
doaj   +1 more source