Results 101 to 110 of about 2,567,801 (286)

Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis

Advanced Science, EarlyView.
Amuc_1473, a previously uncharacterized protein enriched in Akkermansia muciniphila‐derived extracellular vesicles, is identified as a gut–bone messenger that promotes osteogenesis and inhibits osteoclastogenesis by engaging transcriptional and translational regulators in bone cells.
Shan‐Shan Rao, Hai‐Jin Zeng, Zun Wang, Chun‐Gu Hong, Yi‐Juan Tan, Yan‐Xin Duan, Jing‐Yao Luo, Ming‐Jie Luo, Yi‐Wei Liu, Xin Wang, Yi Luo, Teng‐Fei Wan, Yong Zhou, Zheng‐Guang Wang, Guo‐Wen Hu, Hao Yin, Xin‐Yue Hu, Zhen‐Xing Wang, Ze‐Hui He, Si‐Yi Cheng, Wei Du, Zhe Guan, Hai‐Li Lang, Hong‐Ji Liu, Jia Cao, Peng Chen, Jiang‐Hua Liu, Hui Xie, Chun‐Yuan Chen   +28 more
wiley   +1 more source

Variability of large-scale atmospheric circulation indices for the northern hemisphere during the past 100 years

Meteorologische Zeitschrift, 2009
We present an analysis of the large-scale atmospheric circulation variability since 1900 based on various circulation indices. They represent the main features of the zonal mean circulation in the northern hemisphere in boreal winter (such as the Hadley ...
Stefan Brönnimann, Alexander Stickler, Thomas Griesser, Andreas M. Fischer, Andrea Grant, Tracy Ewen, Tianjun Zhou, Martin Schraner, Eugene Rozanov, Thomas Peter   +9 more
doaj   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Microphysical, macrophysical and radiative signatures of volcanic aerosols in trade wind cumulus observed by the A-Train

, 2011
. Increased aerosol concentrations can raise planetary albedo not only by reflecting sunlight and increasing cloud albedo, but also by changing cloud amount.
T. Yuan, L. Remer, Hongbin Yu
semanticscholar   +1 more source

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Enhanced precipitation responses over the Tibetan Plateau following future Tambora-size volcanic eruption

Advances in Climate Change Research
Hydroclimate over the Tibetan Plateau (TP) notably influences the eco-environment of the Northern Hemisphere. Given its high elevation and complex topography, the climate in the TP shows a high sensitivity to anthropogenic warming and volcanic-induced ...
Xin-Jun Gan, Lin-Shan Yang, Meng Zuo, Fei Liu, Chao-Chao Gao   +4 more
doaj   +1 more source

Simulation of the climate impact of Mt. Pinatubo eruption using ECHAM5 – Part 1: Sensitivity to the modes of atmospheric circulation and boundary conditions [PDF]

Atmospheric Chemistry and Physics, 2009
The eruption of Mt. Pinatubo in the Philippines in June 1991 was one of the strongest volcanic eruptions in the 20th century and this well observed eruption can serve as an important case study to understand the subsequent weather and climate changes. In
M. A. Thomas, C. Timmreck, M. A. Giorgetta, H.-F. Graf, G. Stenchikov   +4 more
doaj  

Greenhouse Gas Concentration and Volcanic Eruptions Controlled the Variability of Terrestrial Carbon Uptake Over the Last Millennium

Journal of Advances in Modeling Earth Systems, 2019
The terrestrial net biome production (NBP) is considered as one of the major drivers of interannual variation in atmospheric CO2 levels. However, the determinants of variability in NBP under the background climate (i.e., preindustrial conditions) remain ...
Xuanze Zhang, Shushi Peng, Philippe Ciais, Ying‐Ping Wang, Jeremy D. Silver, Shilong Piao, Peter J. Rayner   +6 more
doaj   +1 more source

Small global-mean cooling due to volcanic radiative forcing [PDF]

, 2016
Jonathan M. Gregory, Timothy Andrews, Peter Good, Thorsten Mauritsen, Piers Forster   +4 more
openalex   +1 more source

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

Advanced Science, EarlyView.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li, Zhongshao Chen, Qianqian Gao, Yuehan Gao, Ning Yang   +4 more
wiley   +1 more source