Results 91 to 100 of about 927 (261)

Seasonal ITCZ Control on ENSO Responses to Extratropical Volcanic Forcing

Journal of Climate
Abstract The response of El Niño–Southern Oscillation (ENSO) to a strong volcanic eruption is controlled by several mechanisms, including the spatial structure of the volcanic forcing. In the case of extratropical eruptions, a mechanism contributing to posteruption ENSO evolution involves the forced interhemispheric energy imbalance and the associated ...
Fang, Shih-Wei, Pausata, Francesco, D’agostino, Roberta, Khodri, Myriam, Zanchettin, Davide, Timmreck, Claudia   +5 more
openaire   +3 more sources

Bioadhesive Hydrogel With Polyphenol‐Armored Nanogene Rejuvenates Chondrocyte Senescence for Aged Osteoarthritis Therapy

Advanced Science, EarlyView.
An adhesive hydrogel depot with polyphenol‐armored nanogenes is developed for treating aged osteoarthritis. This system maintains miR‐140 bioactivity, prolongs its intra‐articular retention, and enhances transfection into chondrocytes, leading to the downregulation of senescence‐associated pathways.
Liwei Yan, Runze Yang, Ting Zhou, Tianhao Xu, Yongqi Li, Yuelin Hu, Minghao Ge, Lei Zhang, Xiong Lu, Chaoming Xie, Weili Fu   +10 more
wiley   +1 more source

Variability of large-scale atmospheric circulation indices for the northern hemisphere during the past 100 years

Meteorologische Zeitschrift, 2009
We present an analysis of the large-scale atmospheric circulation variability since 1900 based on various circulation indices. They represent the main features of the zonal mean circulation in the northern hemisphere in boreal winter (such as the Hadley ...
Stefan Brönnimann, Alexander Stickler, Thomas Griesser, Andreas M. Fischer, Andrea Grant, Tracy Ewen, Tianjun Zhou, Martin Schraner, Eugene Rozanov, Thomas Peter   +9 more
doaj   +1 more source

Northeastern Caribbean Rainfall Variability Linked to Solar and Volcanic Forcing

Paleoceanography and Paleoclimatology
AbstractWe present a 500‐year precipitation‐sensitive record based on co‐varying speleothem δ18O values and Mg/Ca ratios from Larga cave in Puerto Rico. This multi‐proxy record shows that the evolution of rainfall in the northeastern Caribbean was characterized by alternating centennial dry and wet phases corresponding to reduced versus enhanced ...
Rolf Vieten, Sophie F. Warken, Davide Zanchettin, Amos Winter, Denis Scholz, David Black, Gabriella Koltai, Christoph Spötl   +7 more
openaire   +2 more sources

Stage‐Adaptive Janus Microneedle System for Redox‐Immune Regulation and Mitochondrial Protection in Infected Diabetic Wound Healing

Advanced Science, EarlyView.
ABSTRACT Infected diabetic wounds are sustained by a vicious cycle of hyperglycemia‐driven bacterial infection, persistent oxidative stress, and excessive inflammation, which collectively disrupt the ordered progression of tissue repair. Here, we engineered a stage‐adaptive Janus microneedle patch (MN‐FeSAC‐PPE) to enable a staged therapeutic process ...
Mengting Yin, Yu Zhang, Xinyu Qu, Jiayi Liu, Zhongyi Sun, Haibo Liu, Ziyan Chen, Jing Ru, Jingwen Han, Bingqiang Lu, Yan Lu, Yan Wang, Xinyu Zhao, Feng Chen   +13 more
wiley   +1 more source

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

Enhanced precipitation responses over the Tibetan Plateau following future Tambora-size volcanic eruption

Advances in Climate Change Research
Hydroclimate over the Tibetan Plateau (TP) notably influences the eco-environment of the Northern Hemisphere. Given its high elevation and complex topography, the climate in the TP shows a high sensitivity to anthropogenic warming and volcanic-induced ...
Xin-Jun Gan, Lin-Shan Yang, Meng Zuo, Fei Liu, Chao-Chao Gao   +4 more
doaj   +1 more source

Simulation of the climate impact of Mt. Pinatubo eruption using ECHAM5 – Part 1: Sensitivity to the modes of atmospheric circulation and boundary conditions [PDF]

Atmospheric Chemistry and Physics, 2009
The eruption of Mt. Pinatubo in the Philippines in June 1991 was one of the strongest volcanic eruptions in the 20th century and this well observed eruption can serve as an important case study to understand the subsequent weather and climate changes. In
M. A. Thomas, C. Timmreck, M. A. Giorgetta, H.-F. Graf, G. Stenchikov   +4 more
doaj  

Greenhouse Gas Concentration and Volcanic Eruptions Controlled the Variability of Terrestrial Carbon Uptake Over the Last Millennium

Journal of Advances in Modeling Earth Systems, 2019
The terrestrial net biome production (NBP) is considered as one of the major drivers of interannual variation in atmospheric CO2 levels. However, the determinants of variability in NBP under the background climate (i.e., preindustrial conditions) remain ...
Xuanze Zhang, Shushi Peng, Philippe Ciais, Ying‐Ping Wang, Jeremy D. Silver, Shilong Piao, Peter J. Rayner   +6 more
doaj   +1 more source

mTORC2 Phosphorylation of GSDME‐N Drives Cullin4B‐Mediated Proteasomal Degradation to Suppress Pyroptosis and Confer Radioresistance in Small Cell Lung Cancer

Advanced Science, EarlyView.
Radioresistance severely limits the efficacy of therapies for small cell lung cancer (SCLC). This study reveals a novel mechanism of resistance driven by the active suppression of pyroptosis. Specifically, the mTORC2 complex directly phosphorylates GSDME‐N and promotes its CUL4B‐mediated ubiquitination and proteasomal degradation.
Qing‐qing Xu, Ci‐ming Sun, Sui‐xian Zhang, Rui Li, Chen‐fei Wu, Zai‐shan Lin, Li Li, Run‐zhe Chen, Qi‐wen Li, Yuan‐yuan Chen, Xuan Li, Ming Chen   +11 more
wiley   +1 more source