Results 71 to 80 of about 2,567,801 (286)

Mesenchymal Stromal Cell‐Mediated Intercellular Communication: Mapping the Interactome for Skeletal Muscle Homeostasis and Regeneration

Advanced Science, EarlyView.
Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu, Edgar E. Perez Carbajal, Yih‐Chii Hwang, Sahil A. Mapkar, Benjamin W. Gilman, Sarah A. Bliss, Lam B. Tran, Kalgi T. Mehta, Jacob O. Banyasz, Ming Yu, Reynold R. Liu, Matthew N. Ly, Christapher S. Morrissey, Michael N. Wosczyna   +13 more
wiley   +1 more source

Soil modulation of Quaternary glacial-interglacial cycles

Geoderma
Sinusoidal Milankovitch orbital variations do not match the sawtooth pattern of descent into glaciation followed by abrupt termination to greenhouse interglacials seen in records of marine shale, speleothems, and ice cores.
Gregory J. Retallack
doaj   +1 more source

A timescale analysis of the Northern Hemisphere temperature response to volcanic and solar forcing [PDF]

Climate of the Past, 2005
The Northern Hemisphere temperature response to volcanic and solar forcing in the time interval 1000–1850 AD is studied using first a set of simulations with an intermediate-complexity climate model, driven by reconstructed forcings.
S. L. Weber
doaj  

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Hunga Tonga–Hunga Ha′apai Volcano Impact Model Observation Comparison (HTHH-MOC) project: experiment protocol and model descriptions [PDF]

Geoscientific Model Development
The 2022 Hunga volcanic eruption injected a significant amount of water vapor and a moderate amount of sulfur dioxide into the stratosphere, causing observable responses in the climate system.
Y. Zhu, Y. Zhu, H. Akiyoshi, V. Aquila, E. Asher, E. Asher, E. M. Bednarz, E. M. Bednarz, S. Bekki, C. Brühl, A. H. Butler, P. Case, S. Chabrillat, G. Chiodo, G. Chiodo, M. Clyne, M. Clyne, P. R. Colarco, P. R. Colarco, S. Dhomse, S. Dhomse, L. Falletti, E. Fleming, E. Fleming, B. Johnson, A. Jörimann, A. Jörimann, A. Jörimann, M. Kovilakam, G. Koren, A. Kuchar, N. Lebas, Q. Liang, C.-C. Liu, G. Mann, G. Mann, M. Manyin, M. Manyin, M. Marchand, O. Morgenstern, O. Morgenstern, O. Morgenstern, P. Newman, L. D. Oman, F. F. Østerstrøm, F. F. Østerstrøm, F. F. Østerstrøm, Y. Peng, D. Plummer, I. Quaglia, W. Randel, S. Rémy, T. Sekiya, S. Steenrod, S. Steenrod, T. Sukhodolov, S. Tilmes, K. Tsigaridis, K. Tsigaridis, R. Ueyama, D. Visioni, X. Wang, S. Watanabe, S. Watanabe, Y. Yamashita, P. Yu, W. Yu, J. Zhang, Z. Zhuo   +68 more
doaj   +1 more source

Consistent multi-decadal variability in global temperature reconstructions and simulations over the Common Era

Nature Geoscience, 2019
Multidecadal surface temperature changes may be forced by natural as well as anthropogenic factors, or arise unforced from the climate system. Distinguishing these factors is essential for estimating sensitivity to multiple climatic forcings and the ...
R. Neukom, L. Barboza, M. Erb, Feng Shi, J. Emile‐Geay, M. Evans, J. Franke, D. Kaufman, Lucie J. Lücke, K. Rehfeld, A. Schurer, Feng Zhu, S. Brönnimann, G. Hakim, B. Henley, F. Ljungqvist, N. McKay, Veronika Valler, L. von Gunten   +18 more
semanticscholar   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Attribution analyses of temperature extremes using a set of 16 indices

Weather and Climate Extremes, 2016
Detection and attribution studies have demonstrated that anthropogenic forcings have been driving significant changes in temperature extremes since the middle of the 20th century.
Nikolaos Christidis, Peter A. Stott
doaj   +1 more source

Climate change modulates the stratospheric volcanic sulfate aerosol lifecycle and radiative forcing from tropical eruptions [PDF]

, 2021
Thomas J. Aubry, John Staunton-Sykes, Lauren Marshall, Jim Haywood, Nathan Luke Abraham, Anja Schmidt   +5 more
openalex   +1 more source