Results 71 to 80 of about 927 (261)

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source

Hunga Tonga–Hunga Ha′apai Volcano Impact Model Observation Comparison (HTHH-MOC) project: experiment protocol and model descriptions [PDF]

Geoscientific Model Development
The 2022 Hunga volcanic eruption injected a significant amount of water vapor and a moderate amount of sulfur dioxide into the stratosphere, causing observable responses in the climate system.
Y. Zhu, Y. Zhu, H. Akiyoshi, V. Aquila, E. Asher, E. Asher, E. M. Bednarz, E. M. Bednarz, S. Bekki, C. Brühl, A. H. Butler, P. Case, S. Chabrillat, G. Chiodo, G. Chiodo, M. Clyne, M. Clyne, P. R. Colarco, P. R. Colarco, S. Dhomse, S. Dhomse, L. Falletti, E. Fleming, E. Fleming, B. Johnson, A. Jörimann, A. Jörimann, A. Jörimann, M. Kovilakam, G. Koren, A. Kuchar, N. Lebas, Q. Liang, C.-C. Liu, G. Mann, G. Mann, M. Manyin, M. Manyin, M. Marchand, O. Morgenstern, O. Morgenstern, O. Morgenstern, P. Newman, L. D. Oman, F. F. Østerstrøm, F. F. Østerstrøm, F. F. Østerstrøm, Y. Peng, D. Plummer, I. Quaglia, W. Randel, S. Rémy, T. Sekiya, S. Steenrod, S. Steenrod, T. Sukhodolov, S. Tilmes, K. Tsigaridis, K. Tsigaridis, R. Ueyama, D. Visioni, X. Wang, S. Watanabe, S. Watanabe, Y. Yamashita, P. Yu, W. Yu, J. Zhang, Z. Zhuo   +68 more
doaj   +1 more source

A Bioinspired Three‐Dimensional High‐Curvature Nano‐Interface Integrated Microfluidic Chip for Small Extracellular Vesicles Enrichment and Machine Learning‐Assisted Prostate Cancer Precision Diagnosis

Advanced Science, EarlyView.
A biotin‐modified artificial insertion peptide functionalized three‐dimensional high‐curvature‐TiO2 nano‐interface was engineered in a microfluidic chip to improve the isolation efficiency of small extracellular vesicles (sEVs). This chip balanced affinity, releasability, and extendibility, enabling high‐throughput recovery of sEVs for downstream ...
Le Wang, Yizhong Liang, Manan Sulaiman, Jiaqi Du, Ming Jiang, Zhihua Wang, Xu Yu, Li Xu   +7 more
wiley   +1 more source

Attribution analyses of temperature extremes using a set of 16 indices

Weather and Climate Extremes, 2016
Detection and attribution studies have demonstrated that anthropogenic forcings have been driving significant changes in temperature extremes since the middle of the 20th century.
Nikolaos Christidis, Peter A. Stott
doaj   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

External forcing of the early 20th century Arctic warming

Tellus: Series A, Dynamic Meteorology and Oceanography, 2013
The observed Arctic warming during the early 20th century was comparable to present-day warming in terms of magnitude. The causes and mechanisms for the early 20th century Arctic warming are less clear and need to be better understood when considering ...
Lingling Suo, Odd Helge Otterå, Mats Bentsen, Yongqi Gao, Ola M. Johannessen   +4 more
doaj   +1 more source

Warfare, Shmittah – and Volcanic Forcing

Journal of Ancient Judaism
Abstract The importance to Jewish history and identity of the events of the 160s BCE cannot be overstated: the Maccabean Revolt against Seleucid rule laid the political groundwork for the emergence of the independent kingdom of Judea and set its ideological direction. Among the critical episodes of that decade mentioned in narrative sources are two
openaire   +1 more source

The Importance of Metal‐Organic Framework Linker Atoms for CO2 Reduction: A DFT Study

Advanced Science, EarlyView.
Using DFT, we examine the role of linker atoms in CO2 reduction on copper‐based metal organic frameworks (Cu MOFs). Our calculations reveal that linker atoms may serve as both CO2 and H‐shuttling sites and suggest linker electrostatics as a descriptor for linker activity. ABSTRACT Although the metal within the secondary building unit of a metal‐organic
Ugochukwu Nwosu, Samira Siahrostami
wiley   +1 more source

Cigarette Smoke‐Induced Alveolar Macrophage Senescence via GEM/SIRT3‐Mediated Mitochondrial Dysfunction

Advanced Science, EarlyView.
Cigarette smoke accelerates the aging of immune cells in the lung. By combining human single‐cell sequencing, cell culture, and mouse models, the authors show that the protein GEM drives mitochondrial damage and senescence in alveolar macrophages by suppressing SIRT3.
Jin Wang, Meidan Wei, Xiangrong Song, Jiaxin Zhang, Lisha Zhang, Sixian Chen, Yaoyu Hu, Hui Gao, Jianxiang Li   +8 more
wiley   +1 more source