Results 121 to 130 of about 1,098,953 (338)

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Distal occurrence of mid-Holocene Whakatane Tephra on the Chatham Islands, New Zealand, and potential for cryptotephra studies

, 2011
The Whakatane Tephra, a rhyolitic tephra erupted ca. 5500 cal. BP from Okataina Volcanic Centre, central North Island, has been identified on the Chatham Islands which lie ˜900 km east of Christchurch, New Zealand.
Lowe, David J., Holt, Katherine A., Wallace, R. Clel, Hogg, Alan G., David J. Lowe, Katherine A. Holt, Alan G. Hogg, R. Clel Wallace   +7 more
core   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Probabilistic hazard analysis for tsunamis generated by subaqueous volcanic explosions in the Campi Flegrei caldera, Italy

Journal of Volcanology and Geothermal Research, 2019
A probabilistic hazard analysis of tsunami generated by subaqueous volcanic explosion is applied to the Campi Flegrei caldera (Campania, Italy). An event tree is developed to quantify the tsunami hazard due to the submarine explosions by: i) defining ...
R. Paris, M. Ulvrova, J. Selva, B. Brizuela, A. Costa, A. Grezio, S. Lorito, R. Tonini   +7 more
semanticscholar   +1 more source

Volcanic hazard impacts to critical infrastructure: A review [PDF]

, 2014
Effective natural hazard risk assessment requires the characterisation of both hazards and vulnerabilities of exposed elements. Volcanic hazard assessment is at an advanced state and is a considerable focus of volcanic scientific inquiry, whereas ...
Wilson, T.M., Deligne, N.I., Cole, J.W., Wilson, G.   +3 more
core   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

Il rilievo laser come tecnica di monitoraggio per i fenomeni di instabilità dei versanti degli edifici vulcanici : il caso dell'Isola di Stromboli

GEOmedia, 2012
La metodologia di rilievo mediante Laser Scanner Aviotrasportato (ALS) per la ricostruzione dettagliata della morfologia consente l’acquisizione di dati tridimensionali di alta precisione da utilizzare per il monitoraggio di fenomeni franosi in ...
Maria Marsella, Carla Nardinocchi, A. Salvatori, S. Scifoni, Alberico Sonnessa   +4 more
doaj   +2 more sources

Volcanic Hazard Assessment of a Monogenetic Volcanic Field with Sporadic and Limited Information: Deterministic Approach for Harrat Lunayyir, Saudi Arabia

GeoHazards
Saudi Arabia is experiencing interactions between ongoing urbanization, tourism growth, infrastructure projects in western regions along the Red Sea, and volcanic hazards. The area contains extensive monogenetic volcanic fields with hundreds of volcanoes
Károly Németh, Abdulrahman Sowaigh, Mahmoud Ashor, Mostafa Toni, Vladimir Sokolov   +4 more
doaj   +1 more source