Results 51 to 60 of about 824,803 (284)

EDNRA Forms a Positive Feedback Loop with the Hippo/YAP Axis to Drive Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong, Boyang Li, Jiahui Xu, Ruonan Lin, Jinghao Pan, Chenlu Fang, Boxiang Zhang, Lucy Yue Lau, Richard J. Aldridge, Elizabeth A. Whitmore, Yi Chen   +10 more
wiley   +1 more source

Activity Enhancement Study of Xinjiang Silica-Alumina Volcanic Rock Powder through Different Activation Processes

Applied Sciences
In response to the dilemma of the scarcity of mineral additions and the high cost of long-distance transport in Hotan, Xinjiang, China, this paper presented an activation process study on the feasibility of volcanic rock powders unique to this region as ...
Shuhong Yang, Yingjie Wu, Huaiyi Wang, Guiquan Yang, Xiangyi Ding, Zhaoxuan Xia   +5 more
doaj   +1 more source

Maximum warning times for imminent volcanic eruptions [PDF]

, 2005
Accelerations in seismicity are important precursors to eruptions at volcanoes reawakening after extended repose intervals. These have previously been quantified for subduction-zone settings in terms of the linkage of crustal faults by shearing ...
Sammonds, PR, Kilburn, CRJ
core  

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Diagenetic Evolution of Syngenetic Volcanogenic Sediment and Their Influence on Sandstone Reservoir: A Case Study in the Southern Huizhou Sag, Pearl River Mouth Basin, Northern South China Sea

Journal of Marine Science and Engineering
The Paleogene sandstone reservoir of Huizhou Sag is an important target for deep exploration in the Pearl River Mouth Basin, South China Sea. Because of the intense volcanic activity, it had a significant impact on the development of reservoirs, making ...
Jiahao Chen, Hongtao Zhu, Guangrong Peng, Lin Ding, Zhiwei Zeng, Wei Wang, Wenfang Tao, Fengjuan Zhou   +7 more
doaj   +1 more source

European climate response to tropical volcanic eruptions over the last half millennium [PDF]

, 2007
We analyse the winter and summer climatic signal following 15 major tropical volcanic eruptions over the last half millennium based on multi-proxy reconstructions for Europe. During the first and second post-eruption years we find significant continental
Tett, S. F. B., Wanner, H., Luterbacher, J., Fischer, E. M., Zorita, E., Casty, C.   +5 more
core   +2 more sources

The Landscape of Long Non‐Coding RNAs Provides Insights Into the Domestication and Improvement of Pear Fruit

Advanced Science, EarlyView.
This study reveals that long non‐coding RNAs represent important regulatory components underlying pear domestication and improvement. Integrative multi‐omics analyses identify selected lncRNAs associated with fruit traits, while functional validation uncovers a lignin‐related lncRNA, lncRNA‐pys, that promotes lignin accumulation.
Bobo Song, Peilin Han, Jiaming Li, Xiaolong Li, Xiang Zhang, Jing Fan, Dongliang Liu, Jianfa Cai, Lingchao Zhang, Jun Wu   +9 more
wiley   +1 more source

Characteristics and accumulation mode of volcanic rock reservoir of the Fengcheng Formation in the southern of Mahu Sag, Junggar Basin

地质科技通报
Objective To clarify the oil and gas accumulation patterns and main controlling factors of the thin weathered crust volcanic rock reservoir at the top of Member 2 of the Fengcheng Formation in the southern Mahu Sag(Manan Sag). Methods This paper provides
Xincai YOU, Qi YAN, Mengyao LI, Wenlong DANG, Gang GAO, Xiaobing JIAO, Jun WU, Zhiyuan AN, Lingli ZHU, Yu BAI   +9 more
doaj   +1 more source

Volcanology of tuff rings at Kellyville, Onewhero and Bombay, South Auckland Volcanic Field [PDF]

, 2011
The South Auckland volcanic field hosts 82 volcanic centres over an area of approximately 300 km2 in the Pukekohe, Bombay, Tuakau, Pukekawa and Onewhero regions. The intraplate, monogenetic basaltic volcanic field was active between 1.59 and 0.51 Ma, and
Gibson, April Christina
core  

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source