Results 31 to 40 of about 557 (187)

PolyG Fibrils Coalesce Into Nuclear Ribbons That Engage Proteostasis Machinery in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
In NIID, expanded NOTCH2NLC repeats give rise to nuclear polyG inclusions. Tracer‐guided in situ cryo‐electron tomography enables cross‐scale structural analysis from mouse brain to native neuronal nuclei, revealing dense‐core/peripheral‐halo inclusions built from compact polyG ribbons.
Hui Dong, Yongcheng Pan, Zhiyao Tang, Yuxuan Yao, Guicong Zhang, Junpu Wang, Haonan Xiao, Yun Tian, Beisha Tang, Dan Li, Qiang Guo, Ruijun Tian, Qiong Liu, Cong Liu   +13 more
wiley   +1 more source

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

How a non harmonic-like tremor at a volcanic lake could be caused by sustained wind: A case of study of Taupō volcano

Volcanica
Taupō volcano lies underneath the largest lake in New Zealand. It undergoes unrest roughly every ten years, has minor eruptions every few hundred years, and has supereruptions.
Henriette Bakkar Hindeleh, Martha Savage, Finnigan Illsley-Kemp, Eleanor R. H. Mestel   +3 more
doaj   +1 more source

Identification of senescence‐related genes in Parkinson's disease reveals candidate therapeutic targets and pathological processes

Animal Models and Experimental Medicine, EarlyView.
At the genomic level, a large number of differentially expressed genes (DEGs) and aging‐related DEGs have been screened. Ten hub genes, such as IFNγ and IRF7, have been identified and shown potential value in the diagnosis of PD, holding promise as novel biomarkers to facilitate early and precise diagnosis.
Haojie Wu, Tingting Liu, Xiangshu Cheng, Jianshe Wei   +3 more
wiley   +1 more source

New detection of tremor triggered in Hokkaido, northern Japan by the 2004 Sumatra–Andaman earthquake

Geophysical Research Letters, 2012
The transient stress change caused by the passage of surface waves resulting from the 26 December 2004 Sumatra–Andaman earthquake triggered seismic tremor in two regions in Hokkaido, in the northernmost part of the Japanese islands, where tectonic tremor
Kazushige Obara
doaj   +1 more source

Seismic Data, Photographic Images and Physical Modeling of Volcanic Plumes as a Tool for Monitoring the Activity of Nevado del Ruiz Volcano, Colombia

Frontiers in Earth Science, 2018
Quantification of volcanic plume parameters is a fundamental task to characterize the behavior of an active volcano. The volcanic plume mass, flow rate and ash injection were determined from seismic data, in addition to photographic images and ...
John Makario Londono, John Makario Londono, Beatriz Galvis, Beatriz Galvis   +3 more
doaj   +1 more source

Volcano Opto‐Acoustics: Mapping the Infrasound Wavefield at Yasur Volcano (Vanuatu)

Geophysical Research Letters, 2023
We explore the capabilities of volcano opto‐acoustics, a promising technique for measuring explosion and infrasound resonance phenomena at open‐vent volcanoes.
J. B. Johnson, T. Boyer, L. M. Watson, J. F. Anderson   +3 more
doaj   +1 more source

Monoallelic POLR3A Variants Cause Early‐Onset Peripheral Neuropathy

Annals of Neurology, EarlyView.
Objective Biallelic variants in genes encoding the RNA polymerase III complex (Pol III) cause a spectrum of neurological disorders primarily affecting the central nervous system. Monoallelic variants have been reported in the POLR3B subunit only, associated with neurodevelopmental disorder, epilepsy, and peripheral neuropathy.
Luiza L. P. Ramos, Jevin M. Parmar, Robin Wijngaard, Bianca R. Grosz, Tamas Lazar, Ligia Mateiu, Steve Vucic, Kishore R. Kumar, Dennis Yeow, Laura I. Rudaks, Lonneke de Boer, Annemarie de Vreugd, David A. Koolen, Thatjana Gardeitchik, Anita Cairns, Krishnan Iyengar, Fernando Kok, Fernanda Barbosa Figueiredo, Alzira Alves de Siqueira Carvalho, Luiz S. Mageste Barbosa, Rodrigo Rezende Arantes, Tyler Rehbein, Jordan E. Bontrager, Elizabeth P. Wood, Janet E. Sowden, Gavin Monahan, Meutia Kumaheri, Ivy Cuijt, Melina Ellis, Gonzalo Perez‐Siles, Elyshia McNamara, Ronald van Beek, Celine B. Meijers, Ivaylo Tournev, Stephan Zuchner, Shoshana J. Wodak, Clara D. M. van Karnebeek, Nigel Laing, Liana N. Semcesen, David A. Stroud, David N. Herrmann, Velina Guergueltcheva, Marina L. Kennerson, Machteld M. Oud, Gianina Ravenscroft, Ayse Candayan, Albena Jordanova   +46 more
wiley   +1 more source

Constraining the wavefield of volcano-seismic events on Mt. Etna, Italy through a rotational sensor and seismic array observations [PDF]

Solid Earth
Long-period (LP) events and tremor are characteristic seismic signals of active volcanoes, offering insight into underlying fluid-driven processes. However, their emergent wavefield is complex and challenging to characterise.
N. I. K. Vesely, E. P. S. Eibl, G. Currenti, M. Sciotto, G. Di Grazia, M. Ohrnberger, P. Jousset   +6 more
doaj   +1 more source

Linking the flow-induced tremor model to the seismological observation: application to the deep harmonic tremor at Hakone volcano, Japan

Earth, Planets and Space, 2023
Decades ago, Julian (J Volcanol Geotherm Res 101:19–26, 1994. https://doi.org/10.1029/93JB03129 ) proposed the lumped parameter model of non-linear excitation of an elastic channel vibration by fluid flow as a mechanism of volcanic harmonic tremor. Since
Tomonori Ozaki, Yohei Yukutake, Mie Ichihara   +2 more
doaj   +1 more source