Results 61 to 70 of about 256,624 (343)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Linking Subsurface to Surface Using Gas Emission and Melt Inclusion Data at Mount Cleveland Volcano, Alaska

Geochemistry, Geophysics, Geosystems, 2020
Mount Cleveland is one of Alaska's most active volcanoes, yet little is known about the magmatic system driving persistent and dynamic volcanic activity.
C. Werner, D. J. Rasmussen, T. Plank, P. J. Kelly, C. Kern, T. Lopez, J. Gliss, J. A. Power, D. C. Roman, P. Izbekov, J. Lyons   +10 more
doaj   +1 more source

Stable operation process of earthquake early warning system based on machine learning: trial test and management perspective

Frontiers in Earth Science, 2023
Earthquake Early Warning (EEW) is an alert system, based on seismic wave propagation theory, to reduce human casualties. EEW systems mainly utilize technologies through both network-based and on-site methods.
Jae-Kwang Ahn, Euna Park, Byeonghak Kim, Eui-Hong Hwang, Seongwon Hong   +4 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

A generalized deep learning model to detect and classify volcano seismicity

Volcanica
Volcano seismicity is often detected and classified based on its spectral properties. However, the wide variety of volcano seismic signals and increasing amounts of data make accurate, consistent, and efficient detection and classification challenging ...
David Fee, Darren Tan, John Lyons, Mariangela Sciotto, Andrea Cannata, Alicia Hotovec-Ellis, Társilo Girona, Aaron Wech, Diana Roman, Matthew Haney, Silvio De Angelis   +10 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Pyroclastic density currents associated with the 2015 phreatomagmatic eruption of the Kuchinoerabujima volcano

Earth, Planets and Space, 2018
A pyroclastic density current (PDC) was observed with the phreatomagmatic eruption of the Kuchinoerabujima volcano, southern Japan, on May 29, 2015. The PDC flowed down in all direction from the source crater, forming three major branches.
Nobuo Geshi, Jun’ichi Itoh
doaj   +1 more source

On the phenomena of volcanoes [PDF]

Abstracts of the Papers Printed in the Philosophical Transactions of the Royal Society of London
In a paper on the Decomposition of the Earths, published in the Philosophical Transactions for 1812, the author offered it as a conjecture that the metals of the alkalies and earths might exist in the interior of the globe, and on being exposed to the action of air and water, give rise to volcanic fire and to the production of lavas; by the slow ...
openaire   +5 more sources

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source