Results 71 to 80 of about 242,577 (288)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Tube coalescence in the Jingfudong lava tube and implications for lava flow hazard of Tengchong volcanism

International Journal of Speleology, 2016
Tube-fed structure occurs as a general phenomenon in Tengchong basic lavas, such as lava tubes, lava plugs and tube-related collapse depressions. We deduced the development of Laoguipo lava flows, which is the longest lava tube (Jingfudong lava tube ...
Zhengquan Chen, Yongshun Liu, Haiquan Wei, Jiandong Xu, Wenfeng Guo   +4 more
doaj   +1 more source

The scientific–community interface over the fifteen-year eruptive episode of Tungurahua Volcano, Ecuador

Journal of Applied Volcanology, 2015
The successful handling of Tungurahua’s frequent eruptions during 15 years via permanent instrumental monitoring and good community relations by the Instituto Geofísico of the Escuela Politécnica Nacional (IGEPN) is due to these factors: 1./ Instrumental
P. Mothes, H. Yepes, M. Hall, P. Ramón, A. Steele, M. Ruiz   +5 more
semanticscholar   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Automatic identification and quantification of volcanic hotspots in Alaska using HotLINK: the hotspot learning and identification network

Frontiers in Earth Science
An increase in volcanic thermal emissions can indicate subsurface and surface processes that precede, or coincide with, volcanic eruptions. Space-borne infrared sensors can detect hotspots—defined here as localized volcanic thermal emissions—in near-real-
Pablo Saunders-Shultz, Taryn Lopez, Hannah Dietterich, Társilo Girona   +3 more
doaj   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Pyroclastic density currents associated with the 2008-2009 eruption of Chaitén Volcano (Chile): Forest disturbances, deposits, and dynamics

Andean Geology, 2013
Explosive activity at Chaitén Volcano in May 2008 and subsequent dome collapses over the following nine months triggered multiple, small-volume pyroclastic density currents (PDCs).
Jon J. Major, Thomas C. Pierson, Richard P. Hoblitt, Hugo Moreno   +3 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Landslide damage along Araniko highway and Pasang Lhamu highway and regional assessment of landslide hazard related to the Gorkha, Nepal earthquake of 25 April 2015

Geoenvironmental Disasters, 2017
Background The Gorkha, Nepal Mw 7.8 earthquake of 25 April 2015 triggered a large number of coseismic landslides in a broad area. Two highways, Araniko Highway and Pasang Lhamu Highway, that connect Tibet of China and Nepal, were affected seriously by ...
Chong Xu, Yingying Tian, Bengang Zhou, Hongliu Ran, Gaohu Lyu   +4 more
doaj   +1 more source