Results 71 to 80 of about 251,223 (345)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Linking Subsurface to Surface Using Gas Emission and Melt Inclusion Data at Mount Cleveland Volcano, Alaska

Geochemistry, Geophysics, Geosystems, 2020
Mount Cleveland is one of Alaska's most active volcanoes, yet little is known about the magmatic system driving persistent and dynamic volcanic activity.
C. Werner, D. J. Rasmussen, T. Plank, P. J. Kelly, C. Kern, T. Lopez, J. Gliss, J. A. Power, D. C. Roman, P. Izbekov, J. Lyons   +10 more
doaj   +1 more source

Stable operation process of earthquake early warning system based on machine learning: trial test and management perspective

Frontiers in Earth Science, 2023
Earthquake Early Warning (EEW) is an alert system, based on seismic wave propagation theory, to reduce human casualties. EEW systems mainly utilize technologies through both network-based and on-site methods.
Jae-Kwang Ahn, Euna Park, Byeonghak Kim, Eui-Hong Hwang, Seongwon Hong   +4 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Lava fountain jet noise during the 2018 eruption of fissure 8 of Kīlauea volcano

Frontiers in Earth Science, 2022
Real-time monitoring is crucial to assess hazards and mitigate risks of sustained volcanic eruptions that last hours to months or more. Sustained eruptions have been shown to produce a low frequency (infrasonic) form of jet noise.
Julia E. Gestrich, David Fee, Robin S. Matoza, John J. Lyons, Hannah R. Dietterich, Valeria Cigala, Ulrich Kueppers, Matthew R. Patrick, Carolyn E. Parcheta   +8 more
doaj   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

A generalized deep learning model to detect and classify volcano seismicity

Volcanica
Volcano seismicity is often detected and classified based on its spectral properties. However, the wide variety of volcano seismic signals and increasing amounts of data make accurate, consistent, and efficient detection and classification challenging ...
David Fee, Darren Tan, John Lyons, Mariangela Sciotto, Andrea Cannata, Alicia Hotovec-Ellis, Társilo Girona, Aaron Wech, Diana Roman, Matthew Haney, Silvio De Angelis   +10 more
doaj   +1 more source

The Volcanoes of Iceland [PDF]

Proceedings of the Yorkshire Geological Society, 1892
The author visited Iceland in the summer of 1890, with the especial object of examining and photographing the volcanic phenomena with which the country abounds. Iceland is an island about the size of Ireland, situated just outside the arctic circle. The inhabited, or habitable, portion is confined to a narrow belt round the shore, the centre portion ...
openaire   +2 more sources

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

Pyroclastic density currents associated with the 2015 phreatomagmatic eruption of the Kuchinoerabujima volcano

Earth, Planets and Space, 2018
A pyroclastic density current (PDC) was observed with the phreatomagmatic eruption of the Kuchinoerabujima volcano, southern Japan, on May 29, 2015. The PDC flowed down in all direction from the source crater, forming three major branches.
Nobuo Geshi, Jun’ichi Itoh
doaj   +1 more source