Results 51 to 60 of about 70,139 (338)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Foundations for Forecasting: Defining Baseline Seismicity at Fuego Volcano, Guatemala

Frontiers in Earth Science, 2018
Accurate volcanic eruption forecasting is especially challenging at open vent volcanoes with persistent low levels of activity and relatively sparse permanent monitoring networks.
Kyle A. Brill, Gregory P. Waite, Gustavo Chigna   +2 more
doaj   +1 more source

dMODELS. A free software package to model volcanic deformation [PDF]

, 2018
Shallow magma accumulation in the crust often results in slight movements of the ground surface that can be measured using standard land-surveying techniques or satellite geodesy.
Battaglia, Maurizio
core  

Thermal structure of a gas-permeable lava dome and timescale separation in its response to perturbation [PDF]

, 2009
The thermal boundary layer at the surface of a volcanic lava dome is investigated through a continuum model of the thermodynamic advection diffusion processes resulting from magmatic gas flow through the dome matrix.
Adrian J. Matthews, Balmforth, Balmforth, Barclay, Barclay, Bourgouin, Calder, Carn, Costa, Couch, Dragoni, Dzurisin, Edmonds, Edmonds, Edmonds, Elsworth, Fink, Francis, Hale, Hale, Hammouya, Herd, Hicks, Hinch, Iverson, Mark J. Cooker, Mastin, Matthews, Matthews, McNutt, McNutt, Melnik, Melnik, Nakada, Neri, Neuberg, Oppenheimer, Peter D. Hicks, Sato, Sigurdsson, Simmons, Sparks, Sparks, Spera, Taron, Urai, Vaughan, Watts, Woods, Yamasato   +49 more
core   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Advances in Understanding Intrusive, Explosive and Effusive Processes as Revealed by the Borehole Dilatometer Network on Mt. Etna Volcano

Frontiers in Earth Science, 2020
For detecting below surface sources of deformation, strain measurements offer a very large advantage (orders of magnitude) in sensitivity over displacement measurements. On active volcanoes an intriguing open challenge is to measure the strain variations
Alessandro Bonaccorso, Gilda Currenti, Alan Linde, Selwyn Sacks, Antonino Sicali   +4 more
doaj   +1 more source

On the monitoring of surface displacement in connection with volcano reactivation in Tenerife, Canary Islands, using space techniques [PDF]

, 2002
Geodetic volcano monitoring in Tenerife has mainly focused on the Las Cañadas Caldera, where a geodetic micronetwork and a levelling profile are located.
Aparicio, A., Carrasco, D., Dalda, A., Fernández, José, González-Matesanz, FJ., Prieto Morin, Juan Francisco, Quirós Donate, Rafael, Rodríguez-Velasco, G., Romero, R., Yu, T.-T.   +9 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Monitoring Active Volcanoes

Eos, Transactions American Geophysical Union, 1996
Monitoring volcanoes is a surprisingly controversial enterprise. Some volcanologists argue that monitoring promises too much and delivers too little for risk mitigation. They trust only strict land‐use measures (and accompanying high insurance premiums in risky zones) and urge that funds be used for public education and awareness rather than for ...
openaire   +2 more sources