Results 61 to 70 of about 30,469 (262)

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Exploiting ground-based optical sensing technologies for volcanic gas surveillance

Annals of Geophysics, 2004
Measurements of volcanic gas composition and flux are crucial to probing and understanding a range of magmatic, hydrothermal and atmospheric interactions.
A. J. S. McGonigle, C. Oppenheimer
doaj   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

2021–2023 Unrest and Geodetic Observations at Askja Volcano, Iceland

Geophysical Research Letters
Unrest began in July 2021 at Askja volcano in the Northern Volcanic Zone (NVZ) of Iceland. Its most recent eruption, in 1961, was predominantly effusive and produced ∼0.1 km3 lava field. The last plinian eruption at Askja occurred in 1875.
Michelle M. Parks, Freysteinn Sigmundsson, Vincent Drouin, Sigrún Hreinsdóttir, Andrew Hooper, Yilin Yang, Benedikt G. Ófeigsson, Erik Sturkell, Ásta R. Hjartardóttir, Ronni Grapenthin, Halldór Geirsson, Elisa Trasatti, Sara Barsotti, Rikke Pedersen, Páll Einarsson, Bergrún A. Óladóttir, Hildur M. Friðriksdóttir   +16 more
doaj   +1 more source

Geomagnetic anomalies observed at volcano Popocatepetl, Mexico [PDF]

Advances in Geosciences, 2008
Results of the ULF geomagnetic monitoring of the volcano Popocatepetl (Mexico) and their analysis are summarized and presented for the period 2003–2006.
A. Kotsarenko, V. Grimalsky, R. Pérez Enríquez, V. Yutsis, S. Koshevaya, J. A. López Cruz-Abeyro, C. Valdez-Gonzalez, R. A. Villegas Cerón   +7 more
doaj  

The recent seismicity of Mt. Vesuvius: inference on seismogenic processes

Annals of Geophysics, 2013
We have analyzed the recent seismicity of Mt. Vesuvius, with particular emphasis on the period 1999-2012. Since 1972 continuous observations with electromagnetic seismometers allowed the compilation of a detailed earthquake catalogue for the station OVO.
Luca D’Auria, Antonietta M. Esposito, Domenico Lo Bascio, Patrizia Ricciolino, Flora Giudicepietro, Marcello Martini, Teresa Caputo, Walter De Cesare, Massimo Orazi, Rosario Peluso, Giovanni Scarpato, Ciro Buonocunto, Marco Capello, Antonio Caputo   +13 more
doaj   +1 more source

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Preface

Annals of Geophysics, 2013
Mt. Vesuvius is one of the most hazardous volcanoes in the world, due to the highly populated surrounding area, where more than 800,000 people live. It experienced various regimes of eruptive activity, from effusive to Plinian.
Francesca Bianco, Stefano Caliro, Mario La Rocca, Umberto Tammaro   +3 more
doaj   +1 more source