Results 71 to 80 of about 30,469 (262)

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Near-real-time design of experiments for seismic monitoring of volcanoes

Seismica
Monitoring the seismic activity of volcanoes is crucial for hazard assessment and eruption forecasting. The layout of each seismic network determines the information content of recorded data about volcanic earthquakes, and experimental design methods ...
Dominik Strutz, Andrew Curtis
doaj   +1 more source

Neural networks and dynamical system techniques for volcanic tremor analysis

Annals of Geophysics, 1996
A volcano can be seen as a dynamical system, the number of state variables being its dimension N. The state is usually confined on a manifold with a lower dimension f, manifold which is characteristic of a persistent «structural configuration».
R. Carniel
doaj   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Could seismo-volcanic catalogs be improved or created using weakly supervised approaches with pre-trained systems? [PDF]

Natural Hazards and Earth System Sciences
Real-time monitoring of volcano-seismic signals is complex. Typically, automatic systems are built by learning from large seismic catalogs, where each instance has a label indicating its source mechanism.
M. Titos, M. Titos, C. Benítez, C. Benítez, L. D'Auria, M. Kowsari, J. M. Ibáñez, J. M. Ibáñez   +7 more
doaj   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

3D Habitat Complexity and Coral Morphology Modulate Reef Fish Functional Structure in a Marine National Park

Ecology and Evolution
The ongoing degradation of coral reef habitats is widely acknowledged to have adverse effects on the abundance and diversity of reef fish populations, yet the direct effects on ecosystem functions remain uncertain. This study used a quantitative approach
Sofia B. Ferreira, John H. R. Burns, Atsuko Fukunaga, Lillian J. Tuttle Raz, Sheila A. McKenna, Kailea Annandale, Ryan J. Monello   +6 more
doaj   +1 more source

Potential laharic risks associated with the Millennium Eruption products of Tianchi volcano, NE China

Natural Hazards Research
Tianchi volcano has experienced continuous eruptions, including the Millennium Eruption (ME) event that produced a volcanic explosivity index of 6–7 in approximately 946 CE, which is among the most hazardous eruptions in human history.
Zhengquan Chen, Haiquan Wei, Yuan Wan, Bo Zhao, Xiaoxuan Li   +4 more
doaj   +1 more source

Alaska Volcano Observatory Alert and Forecasting Timeliness: 1989–2017

Frontiers in Earth Science, 2018
The Alaska Volcano Observatory (AVO) monitors volcanoes in Alaska and issues notifications and warnings of volcanic unrest and eruption. We evaluate the timeliness and accuracy of eruption forecasts for 53 eruptions at 20 volcanoes, beginning with Mount ...
Cheryl E. Cameron, Stephanie G. Prejean, Michelle L. Coombs, Kristi L. Wallace, John A. Power, Diana C. Roman   +5 more
doaj   +1 more source