Results 81 to 90 of about 1,019,029 (303)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Parallel current-controlled synchronverters for voltage and frequency regulation in weak grids

open access: yesThe Journal of Engineering, 2019
The emulation of synchronous machines is becoming an attractive solution to provide virtual inertia and voltage support to weak grids and microgrids, representing an alternative to conventional current-injection control strategies.
Javier Roldán-Pérez   +2 more
doaj   +1 more source

Effects of VSM convertor control on penetration limits of non-synchronous generation in the GB power system [PDF]

open access: yes, 2016
2013 saw the presentation of a paper [1][2] to the wind integration workshop, which demonstrated 26 high convertor penetration scenarios, 17 of which introduced a type of instability in RMS models previously unseen by the researchers. It also provided an
Booth, Campbell D.   +6 more
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Weak Coupling Effects in the PLL Modes of Grid‐Following PMSG Wind Power Systems

open access: yesIET Renewable Power Generation
Small‐signal synchronisation stability is a critical issue of grid‐connected permanent magnet synchronous generator (PMSG) wind power systems employing grid‐following voltage source converters (VSCs).
Xumeng Cui   +5 more
doaj   +1 more source

High-voltage switch-mode assisted linear amplifier based voltage source for dielectric low frequency-domain spectroscopy measurements

open access: yesThe Journal of Engineering, 2019
This study presents a switch-mode assisted linear amplifier (SMALA) designed for use as a frequency-domain spectroscopy (FDS) excitation voltage source for the diagnostic testing of oil/paper insulation systems in large power transformers.
Shawn D. Nielsen   +2 more
doaj   +1 more source

Testing of the Advanced Stirling Radioisotope Generator Engineering Unit at NASA Glenn Research Center [PDF]

open access: yes
The Advanced Stirling Radioisotope Generator (ASRG) is a high-efficiency generator being developed for potential use on a Discovery 12 space mission. Lockheed Martin designed and fabricated the ASRG Engineering Unit (EU) under contract to the Department ...
Lewandowski, Edward J.
core   +1 more source

Recent Stirling Conversion Technology Developments and Operational Measurements [PDF]

open access: yes, 2009
Under contract to the Department of Energy (DOE), Lockheed Martin Space Systems Company (LMSSC) has been developing the Advanced Stirling Radioisotope Generator (ASRG).
Oriti, Salvatore, Schifer, Nicholas
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Corrected complex torque coefficient method for synchronization stability analysis of grid‐connected VSC

open access: yesIET Renewable Power Generation
Sub‐synchronous oscillation of grid‐connected voltage source converter (VSC) dominated by phase locked loop (PLL) is an important stability issue in nowadays power systems.
Boyuan Zhao   +4 more
doaj   +1 more source

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