Results 81 to 90 of about 21,928 (305)

A conserved mechanism of LRRC8 channel inhibition by two structurally distinct drugs

Communications Biology
Leucine Rich Repeat Containing 8 (LRRC8) anion channels are emerging therapeutic targets, but their pharmacology is poorly developed. We employed a structurally defined homomeric channel chimera (8C-8A(IL125)) and heteromeric LRRC8A/LRRC8C (8A/8C ...
Toshiki Yamada, Paola Bisignano, Erkan Karakas, Jerod S. Denton   +3 more
doaj   +1 more source

Peran Vdac (Voltage Dependent Anion Channel) Terhadap Fungsi Spermatozoa

JURNAL KESEHATAN BHAKTI HUSADA, 2021
Sperma berkualitas baik dibutuhkan untuk keberhasilan proses fertilisasi. Untuk dapat membuahi sel telur, sperma mengalami perubahan-perubahan yang bersifat biokimia maupun biofisik, yaitu proses kapasitasi dan reaksi akrosom. Selain itu sperma harus mempunyai kemampuan gerak yang progresif untuk dapat mencapai sel telur.
openaire   +1 more source

The Role of Voltage-Dependent Anion Channel in Mitochondrial Dysfunction and Human Disease [PDF]

, 2021
Joyce T. Varughese, Susan K. Buchanan, Ashley S. Pitt   +2 more
openalex   +1 more source

‘Oxygen Bound to Magnesium’ as High Voltage Redox Center Causes Sloping of the Potential Profile in Mg‐Doped Layered Oxides for Na‐Ion Batteries

Advanced Functional Materials, EarlyView.
Na‐ion batteries ‐ Impact of doping on the oxygen redox: The sloping potential of NaMg0.1Ni0.4Mn0.5O2 above 4.0 V is caused by a new redox center (arising from the ‘O bound to Mg’), having a higher potential but being more irreversible compared to the ‘O bound to Ni’.
Yongchun Li, Konstantin Köster, Katherine A. Mazzio, Yanan Sun, Annica I. Freytag, Deniz Wong, Christian Schulz, Götz Schuck, Volodymyr Baran, Alba San Jose Mendez, Marcin Zając, Payam Kaghazchi, Philipp Adelhelm   +12 more
wiley   +1 more source

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

Advanced Functional Materials, EarlyView.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu, Mingli Wei, Che Bian, Xiaoshuang Bi, Yaxin Deng, Peifu Xiao, Jiansong Zhao, Yuying Wang, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Li Yang, Hongbo Zhang, Yu Zhang   +14 more
wiley   +1 more source

DNA‐Templated 2D Heterostructures as Phototriggered Dynamic Nanohybrids: From Releasing Molecular Loads to Controlling Enzyme Biocatalytic Function

Advanced Functional Materials, EarlyView.
DNA strands are employed both as dynamic linkers and nanoscale templates for the integration of Ag2S nanoparticles on MoS2, which in turn imparted photothermal responsiveness; this feature permits the selective cargo (fluorophore, quantum dots or an enzyme) release from the MoS2 surface in response to local heat induced by light irradiation.
Kai Chen, Haosen Miao, Weiying Hong, Matteo Palma   +3 more
wiley   +1 more source

Mechanotransducing Organic Electrochemical Diode for Crosstalk‐Inhibited Artificial Skin

Advanced Functional Materials, EarlyView.
An innovative approach is presented to a stretchable mechanotransducing diode that unifies rectification and tactile‐sensing functionality. This approach enables to fabricate the diode that maintains a large rectification ratio (5 × 102) at a high operational frequency (100 Hz).
Taeyeong Kim, Seunggoo Baek, Garrett Lecroy, Hyeongseok Choi, Wonjeong Suh, Woosung Cho, Alberto Salleo, Unyong Jeong   +7 more
wiley   +1 more source

In vivo imaging in mouse spinal cord reveals that microglia prevent degeneration of injured axons

Nature Communications
Microglia, the primary immune cells in the central nervous system, play a critical role in regulating neuronal function and fate through their interaction with neurons. Despite extensive research, the specific functions and mechanisms of microglia-neuron
Wanjie Wu, Yingzhu He, Yujun Chen, Yiming Fu, Sicong He, Kai Liu, Jianan Y. Qu   +6 more
doaj   +1 more source

Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy

Advanced Functional Materials, EarlyView.
FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao, Yejing Zhu, Hengchao Yu, Jun Zhu, Bo Wang, Yu Qiao, Zhimin Tian, Junlong Zhao, Lei Liu   +8 more
wiley   +1 more source

Characterisation of detergent-insoluble membranes in pollen tubes of Nicotiana tabacum (L.)

Biology Open, 2015
Pollen tubes are the vehicle for sperm cell delivery to the embryo sac during fertilisation of Angiosperms. They provide an intriguing model for unravelling mechanisms of growing to extremes.
Alessandra Moscatelli, Assunta Gagliardi, Lilly Maneta-Peyret, Luca Bini, Nadia Stroppa, Elisabetta Onelli, Claudia Landi, Monica Scali, Aurora Irene Idilli, Patrick Moreau   +9 more
doaj   +1 more source