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Voltage-dependent calcium channels: From structure to function [PDF]
, 2005 Voltage-activated calcium channels regulate the intracellular calcium concentration and contribute thereby to calcium signalling in numerous cell types. These channels are widely distributed in the animal kingdom and are an essential part of many excitable and non-excitable mammalian cells.
Franz Hofmann +2 more
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Voltage-dependent Calcium Channels of Smooth Muscle Cells
Journal of Cardiovascular Pharmacology, 1988Channels highly selective for calcium, which open when the membrane is depolarized, have been found in all smooth muscle cells examined, whether or not they can generate action potentials. The current through these channels can also be carried by barium and is blocked by cadmium, cobalt, or manganese.
I. MacKENZIE +2 more
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Structural properties of voltage-dependent calcium channels.
International review of cytology, 1993Following purification using Ca2+ channel drugs as ligands, the skeletal muscle Ca2+ channel was shown to be a five-subunit structure containing one large (175 kDa) protein that is the pore and four auxiliary subunits. Each subunit has been cloned and expression studies are proceeding rapidly.
Mary D. Womack +2 more
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Voltage-Dependent Calcium Channels in Glial Cells
Science, 1984The electrophysiological properties of glial cells were examined in primary culture in the presence of tetraethylammonium and Ba 2+ , a treatment that reduces K + permeability of the membrane and enhances currents through voltage-dependent Ca 2+ channels.
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Molecular determinants of voltage-dependent inactivation in calcium channels
Nature, 1994Voltage-dependent Ca2+ channels respond to membrane depolarization by conformational changes that control channel opening and eventual closing by inactivation. The kinetics of inactivation differ considerably between types of Ca2+ channels and are important in determining the amount of Ca2+ entry during electrical activity and its resulting impact on ...
Richard W. Aldrich +3 more
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Voltage‐Dependent Calcium Channel Mutations in Neurological Disease
Annals of the New York Academy of Sciences, 1999ABSTRACT: Calcium ion channel mutations disrupt channel function and create recognizable disease phenotypes in the nervous system. The broad array of underlying cellular alterations is commensurate with the expanding genetic diversity of the voltage‐gated calcium ion channel complex and its critical role in regulating cell function.
Jeffrey L. Noebels, Daniel L. Burgess
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Voltage-dependent calcium channels — beyond dihydropyridine antagonists
Current Opinion in Pharmacology, 2001The blockade of L-type calcium channels by dihydropyridines, phenylalkylamines and benzothiazepines has been well described and forms the basis of a multibillion dollar market for the treatment of cardiovascular disease and migraine. More recently, neuron-specific calcium channels have become the subject of intense interest regarding their potential as
Terrance P. Snutch +2 more
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Voltage dependent calcium channels in mammalian spermatozoa
Frontiers in Bioscience, 1998Calcium influx is an absolute requirement for the physiological acrosome reaction in sperm from all sources examined, both invertebrate and mammalian. Pharmacological studies suggest that the major channel in the sperm head plasma membrane responsible for modulating calcium entry and intracellular ionized calcium levels could be either an L-type (a ...
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Modulation of voltage-dependent calcium channels by G proteins
Current Opinion in Neurobiology, 1998Voltage-gated calcium channels are found in all excitable cells, in which they regulate many important physiological functions, including excitability, gene transcription, muscle contraction, and neurotransmitter and hormone release. The differential modulation of calcium channels by intracellular second messengers constitutes a key mechanism for ...
Gerald W. Zamponi, Terry P. Snutch
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Voltage-dependent calcium channels in mammalian spermatozoa revisited
Frontiers in Bioscience, 2007The last few years have seen an explosion in the number of voltage-dependent ion channel sequences detected in sperm and testes. The complex structural paradigm of these channels is now known to include a pore-forming alpha1 subunit(s) whose electrophysiological properties are modulated by an intracellular beta subunit, a disulfide-linked complex of a ...
Ian R. Hurley +5 more
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