Results 61 to 70 of about 248,505 (393)

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Evidence for a sodium/calcium exchanger and voltage‐dependent calcium channels in adipocytes

FEBS Letters, 1989
The objective of these studies is to identify and characterize Ca2+‐transport systems that may be of potential importance in the action of Ca2+‐mobilizing hormones in the adipocyte. Using the Ca2+‐sensitive photoprotein, aequorin, [Ca2+]i was estimated to be 0.15 μM, assuming an intracellular [Mg2+] of 1 mM.
Kenneth W. Snowdowne, Harrihar A. Pershadsingh, L.-Y. Lee   +2 more
openaire   +3 more sources

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Lack of direct evidence for a functional role of voltage-operated calcium channels in juxtaglomerular cells [PDF]

, 1990
In this study we have examined the role of voltage-gated calcium channels in the regulation of calcium in juxtaglomerular cells. Using a combination of patch-clamp and single-cell calcium measurement we obtained evidence neither for voltage-operated ...
Chegini, S., Kurtz, Armin, Penner, R., Skott, O.   +3 more
core   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

The DEG/ENaC cation channel protein UNC-8 drives activity-dependent synapse removal in remodeling GABAergic neurons

eLife, 2016
Genetic programming and neural activity drive synaptic remodeling in developing neural circuits, but the molecular components that link these pathways are poorly understood. Here we show that the C.
Tyne W Miller-Fleming, Sarah C Petersen, Laura Manning, Cristina Matthewman, Megan Gornet, Allison Beers, Sayaka Hori, Shohei Mitani, Laura Bianchi, Janet Richmond, David M Miller III   +10 more
doaj   +1 more source

Characterization of voltage-gated Ca(2+) conductances in layer 5 neocortical pyramidal neurons from rats. [PDF]

PLoS ONE, 2009
Neuronal voltage-gated Ca(2+) channels are involved in electrical signalling and in converting these signals into cytoplasmic calcium changes. One important function of voltage-gated Ca(2+) channels is generating regenerative dendritic Ca(2+) spikes ...
Mara Almog, Alon Korngreen
doaj   +1 more source

Postsynaptic Ca2+, but not cumulative depolarization, is necessary for the induction of associative plasticity in Hermissenda [PDF]

, 1993
The neuronal modifications that underlie associative memory in Hermissenda have their origins in a synaptic interaction between the visual and vestibular systems, and can be mimicked by contiguous in vitro stimulation of these converging pathways. At the
Matzel, R. F, Rogers, Ronald F
core   +2 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

The α2δ-like Protein Cachd1 Increases N-type Calcium Currents and Cell Surface Expression and Competes with α2δ-1

Cell Reports, 2018
Summary: Voltage-gated calcium channel auxiliary α2δ subunits are important for channel trafficking and function. Here, we compare the effects of α2δ-1 and an α2δ-like protein called Cachd1 on neuronal N-type (CaV2.2) channels, which are important in ...
Shehrazade Dahimene, Karen M. Page, Ivan Kadurin, Laurent Ferron, Dominique Y. Ho, Gareth T. Powell, Wendy S. Pratt, Stephen W. Wilson, Annette C. Dolphin   +8 more
doaj   +1 more source