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Diversity of Mammalian Voltage‐Gated Sodium Channels
Annals of the New York Academy of Sciences, 1999ABSTRACT: A variety of different isoforms of mammalian voltage‐gated sodium channels have been identified. These channels can be classified into three different types. Eight type 1 isoforms have been identified in the CNS, PNS, skeletal muscle, and heart.
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Voltage‐gated sodium channels and pain pathways
Journal of Neurobiology, 2004AbstractAcute, inflammatory, and neuropathic pain can all be attenuated or abolished by local treatment with sodium channel blockers such as lidocaine. The peripheral input that drives pain perception thus depends on the presence of functional voltage‐gated sodium channels.
John N, Wood +3 more
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Evolutionary History of Voltage-Gated Sodium Channels
2017Every cell within living organisms actively maintains an intracellular Na+ concentration that is 10-12 times lower than the extracellular concentration. The cells then utilize this transmembrane Na+ concentration gradient as a driving force to produce electrical signals, sometimes in the form of action potentials.
Atsuo, Nishino, Yasushi, Okamura
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pH Modulation of Voltage-Gated Sodium Channels
2018Changes in blood and tissue pH accompany physiological and pathophysiological conditions including exercise, cardiac ischemia, ischemic stroke, and cocaine ingestion. These conditions are known to trigger the symptoms of electrical diseases in patients carrying sodium channel mutations.
Colin H, Peters +3 more
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Effects of Benzothiazolamines on Voltage-Gated Sodium Channels
2017Benzothiazole is a versatile fused heterocycle that aroused much interest in drug discovery as anticonvulsant, neuroprotective, analgesic, anti-inflammatory, antimicrobial, and anticancer. Two benzothiazolamines, riluzole and lubeluzole, are known blockers of voltage-gated sodium (Nav) channels.
Farinato, Alessandro +2 more
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Toxins That Affect Voltage-Gated Sodium Channels
2017Voltage-gated sodium channels (VGSCs) are critical in generation and conduction of electrical signals in multiple excitable tissues. Natural toxins, produced by animal, plant, and microorganisms, target VGSCs through diverse strategies developed over millions of years of evolutions.
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