Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
High Gain, Low Noise and Power Transimpedance Amplifier Based on Second Generation Voltage Conveyor in 65 nm CMOS Technology. [PDF]
Sensors (Basel), 2022 García-Montesdeoca JC +2 more
europepmc +1 more source
Effects of VSM convertor control on penetration limits of non-synchronous generation in the GB power system [PDF]
, 2016 2013 saw the presentation of a paper [1][2] to the wind integration workshop, which demonstrated 26 high convertor penetration scenarios, 17 of which introduced a type of instability in RMS models previously unseen by the researchers. It also provided an
Booth, Campbell D. +6 more
core
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Advanced Stirling Radioisotope Generator Engineering Unit 2 Anomaly Investigation [PDF]
The Advanced Stirling Radioisotope Generator (ASRG) Engineering Unit 2 (EU2) is the highest fidelity electrically heated Stirling radioisotope generator built to date.
Dobbs, Michael W. +2 more
core +1 more source
FEBS Open Bio, EarlyView.Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata +13 more
wiley +1 more source
Overview of Stirling Technology Research at NASA Glenn Research Center [PDF]
Stirling Radioisotope Power Systems (RPS) are under development to provide power on future space science missions where robotic spacecraft will orbit, flyby, land or rove using less than a quarter of the plutonium the currently available RPS uses to ...
Metscher, Jonathan F. +3 more
core +1 more source
Association of Corticospinal Tract Asymmetry With Ambulatory Ability After Intracerebral Hemorrhage
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Ambulatory ability after intracerebral hemorrhage (ICH) is important to patients. We tested whether asymmetry between ipsi‐ and contra‐lesional corticospinal tracts (CSTs) assessed by diffusion tensor imaging (DTI) is associated with post‐ICH ambulation.
Yasmin N. Aziz +25 more
wiley +1 more source
Recent Progress of Switching Power Management for Triboelectric Nanogenerators. [PDF]
Sensors (Basel), 2022 Zhou H +9 more
europepmc +1 more source