Results 51 to 60 of about 340,414 (268)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A modified control strategy for LCC with IGCT‐based full‐bridge submodules to solve the commutation failure issues

IET Power Electronics
To solve the commutation failure (CF) issues in high voltage direct current (HVDC) transmission systems based on line commutated converter (LCC), this paper proposes a hybrid solution combining the LCC inverter with the continuously controlled IGCT‐based
Yindi Liu, Xiangjun Zeng, Yiping Luo, Haitao Qu   +3 more
doaj   +1 more source

Novel protection method for VSC-HVDC transmission lines

The Journal of Engineering, 2019
The large shunt capacitances on both sides of VSC-HVDC transmission line will block and reflect the travelling waves when a fault occurs on DC cable lines.
Lingtong Jiang, Qing Chen, Lei Wang, Pu Zhao, Yu Zeng, Wudi Huang   +5 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Control scheme for multi-terminal VSC-based medium-voltage DC distribution networks

The Journal of Engineering, 2019
With the development and application of voltage source converter (VSC) high voltage direct current (HVDC) technology, DC distribution is gradually attracting the attention of researchers in recent years. However, many studies are still in the theoretical
Yirun Ji, Zhichang Yuan, Zhichang Yuan, Jianfeng Zhao, Yuming Zhao, Guoxiang Li, Yan Li   +6 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Comparison of DC linear and non-linear models for multi-terminal VSC HVDC networks

The Journal of Engineering, 2019
The analysis and control design of multi-terminal VSC-HVDC systems requires a linearised model of these inherently non-linear systems. This paper develops such a model, from converter to multi-terminal system, discusses the key concepts and shows its use
Jesus Carmona-Sanchez, Ognjen Marjanovic, Mike Barnes, Wenyuan Wang   +3 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Transient stability analysis of virtual synchronous generator with current saturation by multiple Lyapunov functions method

IET Generation, Transmission & Distribution
This paper demonstrates that the switching of one grid‐connected virtual synchronous generator (VSG) between two control modes, namely constant voltage control (CVC) and current limiting control (CLC) happens at the derived two switching lines.
Yujun Li, Jingrui Liu, Yonghui Liu, Songhao Yang, Zhengchun Du   +4 more
doaj   +1 more source

Self-organising technique for carrier synchronisation and phase offset distribution in modular, fault-tolerant converters

The Journal of Engineering, 2019
Carrier interleaved pulse width modulated modular multilevel converters provide multiple benefits including increased effective switching frequency, switching frequency harmonic elimination, and reduced filter requirements. For converters comprising high
Mark A. H. Broadmeadow, Kenneth D. Sands
doaj   +1 more source