Results 71 to 80 of about 4,139,382 (260)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Grid integration and a power quality assessment of a wave-energy park

IET Smart Grid, 2019
This study presents a step toward the grid connection of a wave-energy park through an electric power conversion system (EPCS) developed and installed for the wave-energy harvesting in Lysekil, Sweden.
Arvind Parwal, Martin Fregelius, Jennifer Leijon, Maria Chatzigiannakou, Olle Svensson, Olle Svensson, Erland Strömstedt, Irina Temiz, Janaina Goncalves de Oliveira, Cecilia Boström, Mats Leijon   +10 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Power cable stresses caused by transmission line faults in next generation VSC-MMC systems

The Journal of Engineering, 2019
Until today, HVDC systems based on Modular Multilevel Voltage Source Converters (VSC-MMC) have exclusively been realised with cross-linked polyethylene (XLPE) cable transmission in monopolar configuration.
Philipp Tünnerhoff, Philipp Ruffing, Philipp Ruffing, Ralf Puffer   +3 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

A second‐order sliding mode control with active disturbance rejection for dynamic voltage restorers

IET Power Electronics
This paper proposes an extended state observer (ESO)‐based second‐order sliding mode control (SMC) for dynamic voltage restorers (DVRs). Unlike the conventional first‐order SMC and some second‐order SMC (SOSMC) methods that suffer from chattering, the ...
Farzaneh Bagheri, Samet Biricik, Hafiz Ahmed, Hasan Komurcugil   +3 more
doaj   +1 more source

Modelling and control of a back-to-back MMC–HVDC system using ADPSS

The Journal of Engineering, 2019
Back-to-back modular multilevel converter–high-voltage direct current (MMC–HVDC) can realise the asynchronous interconnection of two regional power grids. It can effectively solve the power grid stability problems caused by AC–DC power transfer and avoid
Pucheng Cai, Wang Xiang, Jinyu Wen
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Variable DC voltage based reactive power enhancement scheme for MMC‐STATCOM

IET Smart Grid
Constrained by the AC voltage amplitude modulated by a modular multilevel converter‐based static synchronous compensator (MMC‐STATCOM), its reactive power output may be subject to oscillations under grid contingencies, posing a threat to the grid stable ...
Lujie Yu, Guoyan Wang, Tong Wu, Jiebei Zhu, Campbell D. Booth   +4 more
doaj   +1 more source

VSC HVDC active damping for the Sylwin 1 offshore wind power plants

The Journal of Engineering, 2019
SylWin1 is a VSC HVDC link connecting 864 MW offshore wind power generation to Germany's high voltage network. This paper presents a harmonic performance analysis of the offshore network carried out during the design and commissioning phase with a focus ...
Alvaro Hernandez Manchola, Torsten Priebe, Torsten Priebe, Michael Hölzer, Mike Dommaschk   +4 more
doaj   +1 more source