Results 81 to 90 of about 2,792 (271)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Stirling Convertor Controller Development at NASA Glenn Research Center [PDF]

For nearly two decades, NASA Glenn Research Center has been supporting the development of radioisotope power systems (RPS). NASA desires higher conversion efficiency RPS options that are reliable and robust with long-life design. Dynamic conversion, such
Dugala, Gina M.
core   +4 more sources

Power cable stresses caused by transmission line faults in next generation VSC-MMC systems

The Journal of Engineering, 2019
Until today, HVDC systems based on Modular Multilevel Voltage Source Converters (VSC-MMC) have exclusively been realised with cross-linked polyethylene (XLPE) cable transmission in monopolar configuration.
Philipp Tünnerhoff, Philipp Ruffing, Philipp Ruffing, Ralf Puffer   +3 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

A second‐order sliding mode control with active disturbance rejection for dynamic voltage restorers

IET Power Electronics
This paper proposes an extended state observer (ESO)‐based second‐order sliding mode control (SMC) for dynamic voltage restorers (DVRs). Unlike the conventional first‐order SMC and some second‐order SMC (SOSMC) methods that suffer from chattering, the ...
Farzaneh Bagheri, Samet Biricik, Hafiz Ahmed, Hasan Komurcugil   +3 more
doaj   +1 more source

Modelling and control of a back-to-back MMC–HVDC system using ADPSS

The Journal of Engineering, 2019
Back-to-back modular multilevel converter–high-voltage direct current (MMC–HVDC) can realise the asynchronous interconnection of two regional power grids. It can effectively solve the power grid stability problems caused by AC–DC power transfer and avoid
Pucheng Cai, Wang Xiang, Jinyu Wen
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Variable DC voltage based reactive power enhancement scheme for MMC‐STATCOM

IET Smart Grid
Constrained by the AC voltage amplitude modulated by a modular multilevel converter‐based static synchronous compensator (MMC‐STATCOM), its reactive power output may be subject to oscillations under grid contingencies, posing a threat to the grid stable ...
Lujie Yu, Guoyan Wang, Tong Wu, Jiebei Zhu, Campbell D. Booth   +4 more
doaj   +1 more source

VSC HVDC active damping for the Sylwin 1 offshore wind power plants

The Journal of Engineering, 2019
SylWin1 is a VSC HVDC link connecting 864 MW offshore wind power generation to Germany's high voltage network. This paper presents a harmonic performance analysis of the offshore network carried out during the design and commissioning phase with a focus ...
Alvaro Hernandez Manchola, Torsten Priebe, Torsten Priebe, Michael Hölzer, Mike Dommaschk   +4 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source