Results 91 to 100 of about 125,675 (299)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Voltage island-aware multiple voltage assignment based on genetic algorithm(基于遗传算法的电压岛感知的多电压分配)

Zhejiang Daxue xuebao. Lixue ban, 2013
功耗是当前SoC设计所面临的最大挑战之一，多电压设计是一种降低SoC芯片功耗的有效方法.在后布局阶段应用多电压设计，首先对现有电源网络复杂性度量方法进行改进，然后提出了一个同时考虑功耗、电源网络复杂性及电平转换器的新目标函数，并采用遗传算法进行最优电压分配.对GSRC测试电路的实验结果表明，所提出的算法不仅能有效降低芯片功耗，同时可以将多电压设计的额外开销控制在一个较低的水平.此外，改进的电源网络复杂性度量方法在功耗节省和电平转换器数量方面较已有的有一定的优势.
DUShi-min(杜世民), XIAYin-shui(夏银水), QILi-xia(戚利侠)   +2 more
doaj   +1 more source

Performance of Monolayer Graphene Nanomechanical Resonators with Electrical Readout

, 2009
The enormous stiffness and low density of graphene make it an ideal material for nanoelectromechanical (NEMS) applications. We demonstrate fabrication and electrical readout of monolayer graphene resonators, and test their response to changes in mass and
A Huttel, AB Hutchinson, AC Ferrari, B Lassagne, B Witkamp, BI Yakobson, C Lee, CD Dimitrakopoulos, Changyao Chen, D Garcia-Sanchez, E Stolyarova, F Schedin, HJ Mamin, Horst L. Stormer, HWC Postma, HY Chiu, I Bargatin, I Meric, Ioannis Kymissis, J Atalaya, J Moser, James Hone, JS Bunch, JS Bunch, K Jensen, KI Bolotin, Kirill I. Bolotin, KL Ekinci, KS Novoselov, M Ishigami, MD LaHaye, MY Han, MY Huang, N Mohanty, N Mounet, P Blake, P Mohanty, Philip Kim, RA Suleimanov, RG Knobel, S Evoy, Sami Rosenblatt, SC Jun, TMG Mohiuddin, Tony F. Heinz, V Sazonova, W Bao, William Kalb, YT Yang   +48 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Device-spectroscopy of magnetic field effects in a polyfluorene organic light-emitting diode

, 2007
We perform charge-induced absorption and electroluminescence spectroscopy in a polyfluorene organic magnetoresistive device. Our experiments allow us to measure the singlet exciton, triplet exciton and polaron densities in a live device under an applied ...
B. Movaghar, J. Rybicki, M. Wohlgenannt, T. D. Nguyen, U. E. Steiner, Y. Sheng, Z. V. Vardeny   +6 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Combined voltage assignments, factored lifts, and their spectra

We consider lifting eigenvalues and eigenvectors of graphs to their {\em factored lifts}, derived by means of a {\em combined voltage assignment} in a group. The latter extends the concept of (ordinary) voltage assignments known from regular coverings and corresponds to the cases of generalized covers of Potočnik and Toledo (2021) in which a group of ...
Dalfó, C., Fiol, M. A., Pavlíková, S., Širáň, J.   +3 more
openaire   +2 more sources

Interconnection and damping assignment automatic voltage regulator for synchronous generators

International Journal of Electrical Power & Energy Systems, 2018
In this paper a new nonlinear regulation for synchronous generator excitation control is presented. This method comprises the nonlinear Interconnection and Damping Assignment (IDA) method together with the generator voltage feedback giving a nonlinear Automatic Voltage Regulator (AVR).
Jerković Štil, Vedrana, Mehmedović, Muharem   +1 more
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Dynamic Energy Management for Chip Multi-processors under Performance Constraints [PDF]

, 2017
We introduce a novel algorithm for dynamic energy management (DEM) under performance constraints in chip multi-processors (CMPs). Using the novel concept of delayed instructions count, performance loss estimations are calculated at the end of each ...
Ababei, Cristinel, Moghaddam, Milad Ghorbani   +1 more
core   +1 more source