Results 81 to 90 of about 3,524,493 (338)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Engineering Science and Technology, an International Journal, 2018 This paper presents design and experimental evaluation of a single-stage AC/DC converter with PFC and hybrid full-bridge rectifier for supplying LED streetlight. The proposed converter consisted of one LLC resonant tank, two boost circuits and one shared
Nor Azura Samsudin +2 more
doaj +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Active clamp ZVS converter with output voltage doubler
Electronics Letters, 2008 An isolated converter with boost voltage conversion ratio is presented. The active clamp circuit is used to achieve zero voltage switching, release the energy stored in the transformer leakage inductance and limit the voltage stresses on power switches.
B.-R. Lin, J.-J. Chen, Y.-S. Huang
openaire +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Applied SciencesA battery charger for solid-state lithium battery packs was developed and implemented. The power stage used a phase-shifted full-bridge converter integrated with a current-doubler rectifier and synchronous rectification.
Chih-Tsung Chang, Kai-Jun Pai
doaj +1 more source
IEEE Transportation Electrification Conference and Expo, 2018 In this treatise, a new voltage doubler based DC-DC $2\mathrm {L}\mathrm {C}_{\mathrm {m}}-\mathrm {Y}$ power converter topologies are uttered for the high-voltage/low-current renewable energy applications. L-Y, 2L-Y, 2LC-Y and $2\mathrm {L}\mathrm {C}_{\
M. Bhaskar +4 more
semanticscholar +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Very Low Power Cockcroft-Walton Voltage Multiplier for RF Energy Harvesting Applications [PDF]
, 2019 A device was required that could harvest the electromagnetic energy present in ambient radio frequency (RF) signals. A part of this device must convert the AC RF signal received by the antenna into a DC signal that can be used in an embedded application.
Langdon, Trace
core +2 more sources