Results 141 to 150 of about 418,282 (300)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Calibration of ZMPT101B voltage sensor module using polynomial regression for accurate load monitoring [PDF]
, 2017 Smart Electricity is quickly developing as the results of advancements in sensor technology. The accuracy of a sensing device is the backbone of every measurement and the fundamental of every electrical quantity measurement is the voltage and current ...
Abubakar, I. +4 more
core
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Transmission Line Voltage Measurement Utilizing a Calibrated Suspension Grounding Voltage Sensor. [PDF]
Sensors (Basel), 2023 Huang R +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
The Voltage-Sensor S4 Rises to the Occasion in KCNQ2 Channel Activation. [PDF]
Epilepsy Curr, 2023 Stafstrom CE.
europepmc +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
CryoEM structures of Kv1.2 potassium channels, conducting and non-conducting
eLifeWe present near-atomic-resolution cryoEM structures of the mammalian voltage-gated potassium channel Kv1.2 in open, C-type inactivated, toxin-blocked and sodium-bound states at 3.2 Å, 2.5 Å, 3.2 Å, and 2.9 Å.
Yangyu Wu +6 more
doaj +1 more source
Similar voltage-sensor movement in spHCN channels can cause closing, opening, or inactivation. [PDF]
J Gen Physiol, 2023 Wu X +4 more
europepmc +1 more source