Results 151 to 160 of about 125,876 (264)

Quantitative analysis of trafficking defects induced by heterozygous expression of hERG voltage sensor domain variants. [PDF]

Channels (Austin)
Zhang Y, Carr J, Hancox JC, Harmer SC, Dempsey CE.   +4 more
europepmc   +1 more source

Voltage sensor current, SR Ca²⁺ release, and Ca²⁺ channel current during trains of action potential-like depolarizations of skeletal muscle fibers. [PDF]

Physiol Rep, 2023
Bibollet H, Nguyen EL, Miranda DR, Ward CW, Voss AA, Schneider MF, Hernández-Ochoa EO.   +6 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Two-step voltage-sensor activation of the human K_V7.4 channel and effect of a deafness-associated mutation. [PDF]

Nat Commun
Nappi M, Frampton DJA, Kusay AS, Wang K, Yasarbas SS, Pozzi S, Miceli F, Liin SI, Taglialatela M, Pantazis A.   +9 more
europepmc   +1 more source

Construction and Evaluation of an Optical Medium Voltage Transducer Module Aimed at a 132 kV Optical Voltage Sensor for WAMPAC Systems. [PDF]

Sensors (Basel), 2022
Fusiek G, Niewczas P.
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Reinvestigation of Absorption Spectroscopic Thermal Dynamics of Archaerhodopsin 3 Based Voltage Sensor QuasAr1. [PDF]

Bioengineering (Basel)
Penzkofer A, Silapetere A, Hegemann P.
europepmc   +1 more source

Voltage sensor movements of Ca_V1.1 during an action potential in skeletal muscle fibers. [PDF]

Proc Natl Acad Sci U S A, 2021
Banks Q, Bibollet H, Contreras M, Bennett DF, Bannister RA, Schneider MF, Hernández-Ochoa EO.   +6 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Developing a Sensor Payload Module for the Pioneer Robot: Expanding the capabilities of the Pioneer Robot

, 2012
The contents of this project will cover the research and development of a Sensor Module that not only returns some original functions to the Pioneer Robot but also adds an array of more complex sensors.
Leavy, Andrew
core