Results 171 to 180 of about 418,282 (300)

The voltage sensor is responsible for ΔpH dependence in H_v1 channels. [PDF]

Proc Natl Acad Sci U S A, 2021
Carmona EM, Fernandez M, Alvear-Arias JJ, Neely A, Larsson HP, Alvarez O, Garate JA, Latorre R, Gonzalez C.   +8 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Voltage sensor current, SR Ca²⁺ release, and Ca²⁺ channel current during trains of action potential-like depolarizations of skeletal muscle fibers. [PDF]

Physiol Rep, 2023
Bibollet H, Nguyen EL, Miranda DR, Ward CW, Voss AA, Schneider MF, Hernández-Ochoa EO.   +6 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Exceptionally selective voltage-sensor trapping of Na_V1.5 channels by Mg-protoporphyrin impairs cancer cell migration. [PDF]

Sci Rep
Jamili M, Ahmed M, Bernert A, Rößler J, Gessner G, Schönherr R, Hoshi T, Heinemann SH.   +7 more
europepmc   +1 more source

Construction and Evaluation of an Optical Medium Voltage Transducer Module Aimed at a 132 kV Optical Voltage Sensor for WAMPAC Systems. [PDF]

Sensors (Basel), 2022
Fusiek G, Niewczas P.
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Two-step voltage-sensor activation of the human K_V7.4 channel and effect of a deafness-associated mutation. [PDF]

Nat Commun
Nappi M, Frampton DJA, Kusay AS, Wang K, Yasarbas SS, Pozzi S, Miceli F, Liin SI, Taglialatela M, Pantazis A.   +9 more
europepmc   +1 more source

Voltage sensor movements of Ca_V1.1 during an action potential in skeletal muscle fibers. [PDF]

Proc Natl Acad Sci U S A, 2021
Banks Q, Bibollet H, Contreras M, Bennett DF, Bannister RA, Schneider MF, Hernández-Ochoa EO.   +6 more
europepmc   +1 more source