Results 181 to 190 of about 125,876 (264)

PIP₂-dependent coupling of voltage sensor and pore domains in K_v7.2 channel. [PDF]

Commun Biol, 2021
Pant S, Zhang J, Kim EC, Lam K, Chung HJ, Tajkhorshid E.   +5 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Functional control of heteromeric Kv2.1/6.4 channels by the voltage sensor domain of the silent Kv6.4 subunit. [PDF]

J Physiol
Tewari D, Sattler C, Benndorf K.
europepmc   +1 more source

Modulating the voltage sensor of a cardiac potassium channel shows antiarrhythmic effects. [PDF]

Proc Natl Acad Sci U S A, 2021
Lin Y, Grinter SZ, Lu Z, Xu X, Wang HZ, Liang H, Hou P, Gao J, Clausen C, Shi J, Zhao W, Ma Z, Liu Y, White KM, Zhao L, Kang PW, Zhang G, Cohen IS, Zou X, Cui J.   +19 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A propofol binding site in the voltage sensor domain mediates inhibition of HCN1 channel activity. [PDF]

Sci Adv
Burtscher V, Wang L, Cowgill J, Chen ZW, Edge C, Smith E, Chang Y, Delemotte L, Evers AS, Chanda B.   +9 more
europepmc   +1 more source

Augmented Liver Uptake of the Membrane Voltage Sensor Tetraphenylphosphonium Distinguishes Early Fibrosis in a Mouse Model. [PDF]

Front Physiol, 2021
Pandita H, Mezey E, Ganapathy-Kanniappan S.   +2 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A Self-Compensating Non-Intrusive Ring-Type AC Voltage Sensor Based on Capacitive Coupling. [PDF]

Micromachines (Basel)
Wang J, Li J, Peng C, Wu Z, Ju D, Zhang Q.   +5 more
europepmc   +1 more source

ML277 regulates KCNQ1 single-channel amplitudes and kinetics, modified by voltage sensor state. [PDF]

J Gen Physiol, 2021
Eldstrom J, McAfee DA, Dou Y, Wang Y, Fedida D.   +4 more
europepmc   +1 more source