Results 191 to 200 of about 1,906,569 (335)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Two-step voltage-sensor activation of the human K_V7.4 channel and effect of a deafness-associated mutation. [PDF]

Nat Commun
Nappi M, Frampton DJA, Kusay AS, Wang K, Yasarbas SS, Pozzi S, Miceli F, Liin SI, Taglialatela M, Pantazis A.   +9 more
europepmc   +1 more source

Construction and Evaluation of an Optical Medium Voltage Transducer Module Aimed at a 132 kV Optical Voltage Sensor for WAMPAC Systems. [PDF]

Sensors (Basel), 2022
Fusiek G, Niewczas P.
europepmc   +1 more source

Piezoelectric-Actuator Hysteresis Compensation in Student-Built Engineering Education Micropositioning Stages: A Capacitive-Sensor Evaluation Linking Drive-Voltage Sweep to Nanopositioning Repeatability Bounds

Helvi Nangula Amukoto, Tangeni Shikongo Nghipandulwa, Fillemon Nakale Shigwedha   +2 more
openalex   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Direct synaptic excitation between hilar mossy cells revealed with a targeted voltage sensor. [PDF]

Hippocampus, 2021
Ma Y, Bayguinov PO, McMahon SM, Scharfman HE, Jackson MB.   +4 more
europepmc   +1 more source

Eag Kv channel with voltage sensor in the intermediate conformation

NIH 3D
openalex   +1 more source

An ultra steep slope and low voltage split gate oxide dual gate vertical TFET based multi gas sensor [PDF]

Chandaboina Pavan Kumar, Chinna Baji Shaik, Chandan Kumar Pandey, Manish Kumar Singh   +3 more
openalex   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Exceptionally selective voltage-sensor trapping of Na_V1.5 channels by Mg-protoporphyrin impairs cancer cell migration. [PDF]

Sci Rep
Jamili M, Ahmed M, Bernert A, Rößler J, Gessner G, Schönherr R, Hoshi T, Heinemann SH.   +7 more
europepmc   +1 more source