Results 191 to 200 of about 418,282 (300)

Two small-molecule activators share similar effector sites in the KCNQ1 channel pore but have distinct effects on voltage sensor movements. [PDF]

Front Physiol, 2022
Chen L, Peng G, Comollo TW, Zou X, Sampson KJ, Larsson HP, Kass RS.   +6 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Voltage-sensor gating charge interactions bimodally regulate voltage dependence and kinetics of calcium channel activation. [PDF]

J Gen Physiol
Heiss MC, Fernández-Quintero ML, Campiglio M, El Ghaleb Y, Pelizzari S, Loeffler JR, Liedl KR, Tuluc P, Flucher BE.   +8 more
europepmc   +1 more source

Erratum: Augmented Liver Uptake of the Membrane Voltage Sensor Tetraphenylphosphonium Distinguishes Early Fibrosis in a Mouse Model. [PDF]

Front Physiol, 2021
Frontiers Production Office.
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

New Optical Voltage Sensor Based on Closed-Loop Pockels Cell and Sliding Mode Observer: Theory and Experiments. [PDF]

Sensors (Basel)
Quispe-Valencia LM, Higuti RT, Teixeira MCM, Kitano C.   +3 more
europepmc   +1 more source

Structural and Functional Characterization of a Novel Scorpion Toxin that Inhibits Na_V1.8 via Interactions With the DI Voltage Sensor and DII Pore Module. [PDF]

Front Pharmacol, 2022
George K, Lopez-Mateos D, Abd El-Aziz TM, Xiao Y, Kline J, Bao H, Raza S, Stockand JD, Cummins TR, Fornelli L, Rowe MP, Yarov-Yarovoy V, Rowe AH.   +12 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

In vivo Pirt-Marina voltage sensor imaging detects primary sensory neuron-specific voltage dynamics and neuronal plasticity changes. [PDF]

Proc Natl Acad Sci U S A
Zhang Y, Son H, Shannonhouse J, Gomez R, Kim E, Ai CH, Chung MK, Platisa J, Pieribone VA, Kim YS.   +9 more
europepmc   +1 more source

PIP₂-dependent coupling of voltage sensor and pore domains in K_v7.2 channel. [PDF]

Commun Biol, 2021
Pant S, Zhang J, Kim EC, Lam K, Chung HJ, Tajkhorshid E.   +5 more
europepmc   +1 more source