Results 161 to 170 of about 4,346 (212)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
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NMDA Receptors as Voltage Sensors
2017The membrane potential is an essential parameter of a living cell. However, measurements of the membrane potential using conventional techniques are associated with a number of artifacts. Cell-attached recordings of the currents through NMDA receptor channels enable noninvasive measurements of the neuronal membrane potential.
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The voltage-sensor structure in a voltage-gated channel
Trends in Biochemical Sciences, 2005A recent electron paramagnetic resonance study of KvAP, a prokaryotic voltage-gated channel, in its lipid native environment has revealed the location of the transmembrane segments, the connecting loops and the relative position of the voltage-sensing charges.
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Science's STKE, 2002
The voltage sensor for the depolarization-activated, Shaker K + channel (Kv) is well characterized as the transmembrane segment S4. In Kv channels, depolarization stimulates the outward movement (more residues of S4 exposed to the extracellular surface), and the channel opens. Männikkö et al.
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The voltage sensor for the depolarization-activated, Shaker K + channel (Kv) is well characterized as the transmembrane segment S4. In Kv channels, depolarization stimulates the outward movement (more residues of S4 exposed to the extracellular surface), and the channel opens. Männikkö et al.
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Nature Methods, 2014
Genetically encoded voltage indicators are on the brink of allowing neuronal activity to be directly imaged in vivo.
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Genetically encoded voltage indicators are on the brink of allowing neuronal activity to be directly imaged in vivo.
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A Single Circuit Solution for Voltage Sensors
2005 IEEE International Symposium on Circuits and Systems, 2005A single circuit solution using MOSFET alone, has been presented for a voltage sensor. The circuit was implemented in a 0.18 /spl mu/m process for an SRAM application. It was designed to have low temperature sensitivity and good process tuning capability.
S. S. Prasad, Pradip Mandal
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MEMS sensors for high voltage lines
2013 Proceedings of the European Solid-State Device Research Conference (ESSDERC), 2013The paper presents the application for the first time, to our knowledge, of MEMS devices in the field of high power, high voltage lines. We show how these devices can be used for measuring instantaneous voltage value in real-life industrial conditions.
Victor Moagar-Poladian +1 more
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2003
1. ABSTRACT The biological membrane has many functions. Firstly, it is a barrier for most aqueous substances. Life requires compartmentalization: the cell needs an “inside” and an “outside”, which are provided by the cell-wall membrane. However, specific substances must pass through this wall, in a controlled manner.
J.A. Cohen +3 more
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1. ABSTRACT The biological membrane has many functions. Firstly, it is a barrier for most aqueous substances. Life requires compartmentalization: the cell needs an “inside” and an “outside”, which are provided by the cell-wall membrane. However, specific substances must pass through this wall, in a controlled manner.
J.A. Cohen +3 more
openaire +1 more source
High-voltage bidirectional current sensor
2017 IEEE 12th International Conference on ASIC (ASICON), 2017A high-voltage (HV) bidirectional current sensor using fully-differential amplifier (FDA) is designed and analyzed in this investigation. The FDA balances bidirectional input voltages of the HV current sensor by a feedback loop. Thus, the proposed design can detect the direction and magnitude of the current by the difference between the output voltage ...
Zong-You Hou +2 more
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