Results 161 to 170 of about 125,876 (264)

Exceptionally selective voltage-sensor trapping of Na_V1.5 channels by Mg-protoporphyrin impairs cancer cell migration. [PDF]

Sci Rep
Jamili M, Ahmed M, Bernert A, Rößler J, Gessner G, Schönherr R, Hoshi T, Heinemann SH.   +7 more
europepmc   +1 more source

Megahertz Sampling of Prestin (SLC26a5) Voltage-Sensor Charge Movements in Outer Hair Cell Membranes Reveals Ultrasonic Activity that May Support Electromotility and Cochlear Amplification. [PDF]

J Neurosci, 2023
Santos-Sacchi J, Bai JP, Navaratnam D.
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Design and Simulation Test of Non-Contact Voltage Sensor. [PDF]

Sensors (Basel)
Peng H, Liu H, Shang K, Li G, Zhao L.
europepmc   +1 more source

Allosteric interactions among voltage-sensor modules of sodium channels probed by scorpion toxin modifiers. [PDF]

J Neurobiol Physiol, 2022
Gurevitz M, Zhorov BS, Dong K.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Direct synaptic excitation between hilar mossy cells revealed with a targeted voltage sensor. [PDF]

Hippocampus, 2021
Ma Y, Bayguinov PO, McMahon SM, Scharfman HE, Jackson MB.   +4 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Reliable load-balancing routing for resource-constrained wireless sensor networks

, 2012
Wireless sensor networks (WSNs) are energy and resource constrained. Energy limitations make it advantageous to balance radio transmissions across multiple sensor nodes.
Daabaj, Khaled
core  

Voltage sensor conformations induced by LQTS-associated mutations in hERG potassium channels. [PDF]

Nat Commun
Chan AN, Quach CD, Handlin LJ, Lessie EN, Tajkhorshid E, Dai G.   +5 more
europepmc   +1 more source