Results 161 to 170 of about 1,906,569 (335)

Author Correction: A PIP₂ substitute mediates voltage sensor-pore coupling in KCNQ activation. [PDF]

Commun Biol, 2022
Liu Y, Xu X, Gao J, Naffaa MM, Liang H, Shi J, Wang HZ, Yang ND, Hou P, Zhao W, White KM, Kong W, Dou A, Cui A, Zhang G, Cohen IS, Zou X, Cui J.   +17 more
europepmc   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Pore opening, not voltage sensor movement, underpins the voltage-dependence of facilitation by a hERG blocker. [PDF]

Mol Pharmacol, 2022
Furutani K, Kawano R, Ichiwara M, Adachi R, Clancy CE, Sack JT, Kita S.   +6 more
europepmc   +1 more source

Molecular determinants of ligand recognition and efficacy in the TRPM3 voltage sensor-like domain [PDF]

Vikram Dalal, Vipin Ashok Rangari, Samuel Eriksson Lidbrink, Kirby T. Moreland, Erik R. Lindahl, Rebecca J. Howard, Susruta Majumdar, Wayland W.L. Cheng   +7 more
openalex   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Voltage sensor dynamics of a bacterial voltage-gated sodium channel NavAb reveal three conformational states. [PDF]

J Biol Chem, 2023
Han S, Vance J, Jones S, DeCata J, Tran K, Cummings J, Wang S.   +6 more
europepmc   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel. [PDF]

Nat Commun, 2022
Gao X, Schmidpeter PAM, Berka V, Durham RJ, Fan C, Jayaraman V, Nimigean CM.   +6 more
europepmc   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Conformational rearrangements in the second voltage sensor domain switch PIP₂- and voltage-gating modes in two-pore channels. [PDF]

Proc Natl Acad Sci U S A, 2023
Shimomura T, Hirazawa K, Kubo Y.
europepmc   +1 more source