Results 191 to 200 of about 417,703 (296)

Modulating the voltage sensor of a cardiac potassium channel shows antiarrhythmic effects. [PDF]

Proc Natl Acad Sci U S A, 2021
Lin Y, Grinter SZ, Lu Z, Xu X, Wang HZ, Liang H, Hou P, Gao J, Clausen C, Shi J, Zhao W, Ma Z, Liu Y, White KM, Zhao L, Kang PW, Zhang G, Cohen IS, Zou X, Cui J.   +19 more
europepmc   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Functional control of heteromeric Kv2.1/6.4 channels by the voltage sensor domain of the silent Kv6.4 subunit. [PDF]

J Physiol
Tewari D, Sattler C, Benndorf K.
europepmc   +1 more source

Augmented Liver Uptake of the Membrane Voltage Sensor Tetraphenylphosphonium Distinguishes Early Fibrosis in a Mouse Model. [PDF]

Front Physiol, 2021
Pandita H, Mezey E, Ganapathy-Kanniappan S.   +2 more
europepmc   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

A propofol binding site in the voltage sensor domain mediates inhibition of HCN1 channel activity. [PDF]

Sci Adv
Burtscher V, Wang L, Cowgill J, Chen ZW, Edge C, Smith E, Chang Y, Delemotte L, Evers AS, Chanda B.   +9 more
europepmc   +1 more source

Lacosamide Inhibition of Na_V1.7 Channels Depends on its Interaction With the Voltage Sensor Domain and the Channel Pore. [PDF]

Front Pharmacol, 2021
Labau JIR, Alsaloum M, Estacion M, Tanaka B, Dib-Hajj FB, Lauria G, Smeets HJM, Faber CG, Dib-Hajj S, Waxman SG.   +9 more
europepmc   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

A Self-Compensating Non-Intrusive Ring-Type AC Voltage Sensor Based on Capacitive Coupling. [PDF]

Micromachines (Basel)
Wang J, Li J, Peng C, Wu Z, Ju D, Zhang Q.   +5 more
europepmc   +1 more source

ML277 regulates KCNQ1 single-channel amplitudes and kinetics, modified by voltage sensor state. [PDF]

J Gen Physiol, 2021
Eldstrom J, McAfee DA, Dou Y, Wang Y, Fedida D.   +4 more
europepmc   +1 more source