Results 241 to 250 of about 417,703 (296)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
TREX1, a predator for treating MSI‐H tumors?
Molecular Oncology, EarlyView.Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source
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Science Signaling, 2002
The voltage sensor for the depolarization-activated, Shaker K + channel (Kv) is well characterized as the transmembrane segment S4. In Kv channels, depolarization stimulates the outward movement (more residues of S4 exposed to the extracellular surface), and the channel opens. Männikkö et al.
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The voltage sensor for the depolarization-activated, Shaker K + channel (Kv) is well characterized as the transmembrane segment S4. In Kv channels, depolarization stimulates the outward movement (more residues of S4 exposed to the extracellular surface), and the channel opens. Männikkö et al.
openaire +2 more sources
SPIE Proceedings, 1986
The electrooptic Kerr effect is the interaction of an applied electric field with a birefringent fluid medium resulting in a change in the refractive index of the fluid. It has found a variety of applications in the measurement of the applied voltage and electric field by analyzing the polarization rotation of light shined through the fluid. Potentials
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The electrooptic Kerr effect is the interaction of an applied electric field with a birefringent fluid medium resulting in a change in the refractive index of the fluid. It has found a variety of applications in the measurement of the applied voltage and electric field by analyzing the polarization rotation of light shined through the fluid. Potentials
openaire +1 more source
2003
1. ABSTRACT The biological membrane has many functions. Firstly, it is a barrier for most aqueous substances. Life requires compartmentalization: the cell needs an “inside” and an “outside”, which are provided by the cell-wall membrane. However, specific substances must pass through this wall, in a controlled manner.
J.A. Cohen +3 more
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1. ABSTRACT The biological membrane has many functions. Firstly, it is a barrier for most aqueous substances. Life requires compartmentalization: the cell needs an “inside” and an “outside”, which are provided by the cell-wall membrane. However, specific substances must pass through this wall, in a controlled manner.
J.A. Cohen +3 more
openaire +1 more source
A Miniature Smart Voltage Sensor
2021 4th International Conference on Energy, Electrical and Power Engineering (CEEPE), 2021Based on the capacitor voltage divider method, a miniature smart voltage sensing method is proposed, which employs a scheme that dynamically measures the coupling capacitor between the voltage sensor and the ground. Then a prototype of miniature smart voltage sensor (MSVS) is developed.
Zhiming Wang +5 more
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Genetically encoded voltage sensor goes live
Nature Biotechnology, 2013A genetically encoded voltage indicator enables robust optical recording of membrane voltage changes in the fly brain.
James H, Marshel, Karl, Deisseroth
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