Results 251 to 260 of about 1,906,569 (335)
Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni +9 morewiley +1 more sourceEpigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun +9 morewiley +1 more sourceCEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth +3 morewiley +1 more sourcePharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller +16 morewiley +1 more sourcePANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang +4 morewiley +1 more sourceStudy of particle fluence effects on collected charge and depletion voltage of the ATLAS IBL planar pixel sensors
G. Aad, Erlend Aakvaag, B. Abbott, Sara Abdelhameed, K. Abeling, Nils Julius Abicht, S. H. Abidi, Mohammed Aboelela, A. Aboulhorma, H. Abramowicz, B. S. Acharya, Anke Ackermann, Jona Ackerschott, Claire Adam Bourdarios, L. Adamczyk, S. V. Addepalli, Matthew John Addison, J. Adelman, A. Adıgüzel, T. Adye, A. A. Affolder, Y. Afik, M. N. Agaras, A. Aggarwal, C. Agheorghiesei, A. Ahmad, F. Ahmadov, S. Ahuja, S. Ahuja, X. Ai, G. Aielli, A. Aikot, M. Ait Tamlihat, T. P. A. Åkesson, D. Akiyama, Nilima Nilesh Akolkar, S. Aktas, G. L. Alberghi, Justin E Albert, Una Helena Alberti, P. Albicocco, S. Alderweireldt, Z. L. Alegria, M. Aleksa, I. N. Aleksandrov, C. Alexa, T. Alexopoulos, F. Alfonsi, M. Algren, M. Alhroob, B. Ali, H. M. J. Ali, S. Ali, Samuel William Alibocus, Malik Aliev, G. Alimonti, C. Allaire, B. M. M. Allbrooke, David R. Allen, Julia Frances Allen, Julia Frances Allen, C.S. Alley, E. R. Almazan, A. Aloisio, F. Alonso, C. Alpigiani, A. Álvarez Fernández, Mario Alves Cardoso, M. G. Alviggi, M. Aly, Y. Amaral Coutinho, C. Amelung, M. Amerl, Thiziri Amezza, Baktash Amini, Kyle Amirie, Artem Amirkhanov, Dimitra Amperiadou, S. An, C. Anastopoulos, T. Andeen, J. K. Anders, Adam Campbell Anderson, Attilio Andreazza, S. Angelidakis, Aaron Angerami, A. V. Anisenkov, A. Annovi, C. Antel, E. Antipov, M. Antonelli, Fabio Anulli, M. Aoki, T. Aoki, M. A. Aparo, L. Aperio Bella, Mariano Apicella, C. Appelt, A. Apyan, Michaela Arampatzi +99 moreopenalex +1 more sourceIntrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen +10 morewiley +1 more source
