Results 91 to 100 of about 146,756 (305)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Wide input-voltage range boost three-level DC-DC converter with quasi-Z source for fuel cell vehicles [PDF]

, 2016
To solve the problem of the mismatched voltage levels between the dynamic lower voltage of the fuel cell stack and the required constant higher voltage (400V) of the DC link bus of the inverter for fuel cell vehicles, a Boost three-level DC-DC converter ...
Li, Jing, Shi, Jilong, Sumner, Mark, Wang, Ping, Xia, Changliang, Zhang, Yun, Zhou, Lei   +6 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Coordinate Fault Ride-Through Strategy for Connection of Offshore Wind Farms Using Voltage Source-Converter-Based High-Voltage Direct-Current Transmission under Single Polar Fault. [PDF]

Sensors (Basel), 2023
Zhou H, Ge S, Qin L.
europepmc   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Multi-Stage DC-AC Converter Based on new DC-DC converter for energy conversion [PDF]

Journal of Operation and Automation in Power Engineering, 2016
This paper proposes a multi-stage power generation system suitable for renewable energy sources, which is composed of a DC-DC power converter and a three-phase inverter.
Mohammadreza Banaei
doaj  

DC grids for integration of large scale wind power [PDF]

, 2011
It is widely recognized that the future wind power development in the Nordic region will be to a large extent be offshore. The most promising technology for that is the voltage source converter (VSC) HVDC. A review of the most important options and state-
Carlsson, Ola, Cutululis, Nicolaos Antonio, Geisler Eriksen, Anders, Haileselassie, Temesgen, Holbøll, Joachim, Stamatiou, Georgios, Sørensen, Poul Ejnar, Uhlen, Kjetil, Zeni, Lorenzo   +8 more
core   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Analysis of High Step-Up Quasi-Z-Source-Based Converter With Low Input Current Ripple

IEEE Open Journal of the Industrial Electronics Society
This article presents a new high step-up quasi-Z-source-based dc–dc converter with switched boost techniques and voltage multiplier cells. Compared with the conventional Z-source-based converters, this converter not only can achieve high voltage ...
Ataollah Samadian, Milad Ghavipanjeh Marangalu, Iman Talebian, Navid Hadifar, Seyed Hossein Hosseini, Mehran Sabahi, Hani Vahedi   +6 more
doaj   +1 more source