Results 81 to 90 of about 391,586 (309)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Analysis of High Step-Up Quasi-Z-Source-Based Converter With Low Input Current Ripple

open access: yesIEEE Open Journal of the Industrial Electronics Society
This article presents a new high step-up quasi-Z-source-based dc–dc converter with switched boost techniques and voltage multiplier cells. Compared with the conventional Z-source-based converters, this converter not only can achieve high voltage ...
Ataollah Samadian   +6 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Homoclinic Bifurcation of a Grid-Forming Voltage Source Converter

open access: yesIEEE transactions on power electronics, 2021
Jingxi Yang   +3 more
semanticscholar   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

Multi-Stage DC-AC Converter Based on new DC-DC converter for energy conversion [PDF]

open access: yesJournal of Operation and Automation in Power Engineering, 2016
This paper proposes a multi-stage power generation system suitable for renewable energy sources, which is composed of a DC-DC power converter and a three-phase inverter.
Mohammadreza Banaei
doaj  

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Non-isolated high step-up DC–DC converter adopting auxiliary capacitor and coupled inductor

open access: yesJournal of Modern Power Systems and Clean Energy, 2017
For grid-connected power system based on photovoltaic (PV) source and fuel cells, high step-up and high-efficiency DC–DC converters are needed, due to the bus voltage of the grid-connected inverter is much higher than the output voltage of PV and fuel ...
Gang WU, Xinbo RUAN, Zhihong YE
doaj   +1 more source

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