Results 51 to 60 of about 365,222 (314)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

A Trans-Inverse Magnetic Coupling Single-Phase AC-AC Converter

Energies, 2022
This paper introduces a new single-phase AC-AC converter based on an impedance source circuit. Like the existing single-phase impedance source AC-AC converters, it has the buck-boost ability and direct ac conversion.
Soroush Esmaeili, Kasra Ghobadi, Hassan Zare, Mohsin Jamil, Ashraf Ali Khan, Amin Mahmoudi   +5 more
doaj   +1 more source

Grid‐connected medium‐voltage converters with parallel voltage‐source active filters

IET Electric Power Applications, 2019
Grid‐connected medium‐voltage converters are typically operated at switching frequencies of several hundred hertz per switch position, requiring bulky and expensive LCL filters in order to meet the harmonic limits given by the grid code. Commonly, semiconductor current derating and increased switching frequencies are used to reduce the LCL‐filter costs,
Bernet, Daniel, Hiller, Marc
openaire   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

THREE-LEVEL INDIRECT MATRIX CONVERTER WITH TWO SERIES Z-SOURCE NETWORKS [PDF]

Carpathian Journal of Electrical Engineering, 2019
In previous articles, the concept of series Z-source network has been extended to conventional indirect matrix converter to raise the voltage gain to unity and beyond.
Francis Boafo EFFAH, Philip OKYERE, Mubarak Sani ELLIS, Patrick WHEELER, Alan WATSON, Jon CLARE, Joseph OJO   +6 more
doaj  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

A novel bidirectional DC-DC converter

Gong-kuang zidonghua, 2016
For shortages of traditional Buck-Boost converters such as limited output voltage, poor stability, low voltage gain and so on, a novel bidirectional DC-DC converter was designed which used Z-source network to connect DC input power and load.
FANG Xupeng, ZHUANG Jianwei, LI Hui
doaj   +1 more source