Results 81 to 90 of about 91,897 (268)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Static Voltage Stability Assessment of Electricity Networks Using an Enhanced Line-Based Index

Energies
High penetration of renewable energy sources complicates static voltage stability assessment, as conventional line-based indices are typically derived under restrictive assumptions, such as neglecting voltage-angle differences or decoupling active and ...
Zhiquan Zhou, Ashish P. Agalgaonkar, Kashem M. Muttaqi   +2 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Multistability of Phase-Locking and Topological Winding Numbers in Locally Coupled Kuramoto Models on Single-Loop Networks

, 2016
Determining the number of stable phase-locked solutions for locally coupled Kuramoto models is a long-standing mathematical problem with important implications in biology, condensed matter physics and electrical engineering among others.
Coletta, Tommaso, Delabays, Robin, Jacquod, Philippe   +2 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Comparative Analysis of Voltage Stability in Radial Power Distribution Networks Under Critical Loading Conditions and Diverse Load Models

Electricity
Modern power distribution systems are increasingly stressed as they operate closer to their voltage stability limits, driven by growing electricity demand, complex load behaviors, and the evolving structure of power networks. Radial distribution systems,
Salah Mokred, Yifei Wang
doaj   +1 more source

An on-line power/voltage stability index for multi-infeed HVDC systems

Journal of Modern Power Systems and Clean Energy, 2019
High-voltage direct current (HVDC) transmission is playing an increasingly important role in modern power systems, and the resulted power/voltage stability issue has raised widespread concern. This paper presents an on-line power/voltage stability index (
Jian Xu, Tiankai Lan, Siyang Liao, Yuanzhang Sun, Deping Ke, Xiong Li, Jun Yang, Xiaotao Peng   +7 more
doaj   +1 more source

Waveguide propagation of light in polymer porous films filled with nematic liquid crystals

, 2019
We theoretically analyze the waveguide regime of light propagation in a cylindrical pore of a polymer matrix filled with liquid crystals assuming that the effective radial optical anisotropy is biaxial. From numerical analysis of the dispersion relations,
Chopik, A. P., Dubtsov, A. V., Kiselev, Alexei D., Pasechnik, S. V., Semerenko, D. A., Shmeliova, D. V.   +5 more
core   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source