Results 31 to 40 of about 2,773,173 (303)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

LIPIcs, Volume 147, TIME'19, Complete Volume

, 2019
LIPIcs, Volume 147, TIME'19, Complete ...
Pinchinat, Sophie, Sciavicco, Guido, Gamper, Johann   +2 more
core   +1 more source

StateLines Volume 51 No. 27, April 19, 2021

, 2021
Weekly newsletter distributed to the Frostburg State University campus community detailing events, activities, achievements and other ...
StateLines Volume 51 No. 27, April 19, 2021
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

LIPIcs, Volume 136, SNAPL'19, Complete Volume

, 2019
LIPIcs, Volume 136, SNAPL'19, Complete ...
Bodík, Rastislav, Krishnamurthi, Shriram, Lerner, Benjamin S.   +2 more
core   +1 more source

LIPIcs, Volume 138, MFCS'19, Complete Volume [PDF]

, 2019
LIPIcs, Volume 138, MFCS'19, Complete ...
Rossmanith, Peter, Heggernes, Pinar, Katoen, Joost-Pieter   +2 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

OASIcs, Volume 70, LDK'19, Complete Volume

, 2019
OASIcs, Volume 70, LDK'19, Complete ...
Eskevich, Maria, McCrae, John P., Chiarcos, Christian, Dojchinovski, Milan, de Melo, Gerard, Klimek, Bettina, Fäth, Christian, Buitelaar, Paul   +7 more
core   +1 more source

LIPIcs, Volume 126, STACS'19, Complete Volume [PDF]

, 2019
LIPIcs, Volume 126, STACS'19, Complete ...
Niedermeier, Rolf, Paul, Christophe
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source