Results 91 to 100 of about 23,692,773 (298)
Dagstuhl Reports, Volume 5, Issue 4, April 2015, Complete Issue
Dagstuhl Reports, Volume 5, Issue 4, April 2015, Complete ...
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Dagstuhl Reports, Volume 7, Issue 4, April 2017, Complete Issue
Dagstuhl Reports, Volume 7, Issue 4, April 2017, Complete ...
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Dagstuhl Reports, Volume 4, Issue 3, March 2014, Complete Issue
Dagstuhl Reports, Volume 4, Issue 3, March 2014, Complete ...
core +1 more source
(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
openaire +3 more sources

