Results 1 to 10 of about 4,089,988 (286)

Predicting Volume of Distribution in Neonates: Performance of Physiologically Based Pharmacokinetic Modelling [PDF]

Pharmaceutics, 2023
The volume of distribution at steady state (Vss) in neonates is still often estimated through isometric scaling from adult values, disregarding developmental changes beyond body weight.
Pieter-Jan De Sutter, Phebe Rossignol, Lien Breëns, Elke Gasthuys, An Vermeulen   +4 more
doaj   +2 more sources

Interdisciplinary Collaboration on Real World Data to Close the Knowledge Gap: A Reflection on “De Sutter et al. Predicting Volume of Distribution in Neonates: Performance of Physiologically Based Pharmacokinetic Modelling” [PDF]

Pharmaceutics
This commentary further reflects on the paper of De Sutter et al. on predicting volume of distribution in neonates, and the performance of physiologically based pharmacokinetic models We hereby stressed the add on value to collaborate on real world data ...
Karel Allegaert, Anne Smits, Pieter Annaert   +2 more
doaj   +2 more sources

Methods to Predict Volume of Distribution. [PDF]

Curr Pharmacol Rep, 2019
Prior to human studies, knowledge of drug disposition in the body is useful to inform decisions on drug safety and efficacy, first in human dosing, and dosing regimen design. It is therefore of interest to develop predictive models for primary pharmacokinetic parameters, clearance, and volume of distribution.
Holt K, Nagar S, Korzekwa K.
europepmc   +4 more sources

Distribution of Citations in one Volume of a Journal [PDF]

Interdisciplinary Description of Complex Systems, 2013
Citations to published scientific articles are regularly collected and processed, bringing about the impact factor and a large number of other bibliometric indicators.
Antonio Protić, Biserka Runje, Josip Stepanić   +2 more
doaj   +3 more sources

Applying linear and non-linear methods for parallel prediction of volume of distribution and fraction of unbound drug. [PDF]

PLoS ONE, 2013
Volume of distribution and fraction unbound are two key parameters in pharmacokinetics. The fraction unbound describes the portion of free drug in plasma that may extravasate, while volume of distribution describes the tissue access and binding of a drug.
Eva M del Amo, Leo Ghemtio, Henri Xhaard, Marjo Yliperttula, Arto Urtti, Heidi Kidron   +5 more
doaj   +2 more sources

Effects of drug transporters on volume of distribution. [PDF]

AAPS J, 2009
Recently, drug transporters have emerged as significant modifiers of a patient's pharmacokinetics. In cases where the functioning of drug transporters is altered, such as by drug-drug interactions, by genetic polymorphisms, or as evidenced in knockout animals, the resulting change in volume of distribution can lead to a significant change in drug ...
Grover A, Benet LZ.
europepmc   +5 more sources

Conceptos y aplicaciones de los parámetros farmacocinéticos: Una guía para el salón de clases. | [Concepts and applications of pharmacokinetic parameters: A guide for the classroom] [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2023
Context: Pharmacokinetic studies play a fundamental role in making informed decisions during the drug development stage and fulfilling regulatory agencies’ requirements for drug approval.
Jorge Duconge-Soler, Víctor Mangas Sanjuan, Gledys Reynaldo Fernández   +2 more
doaj   +1 more source

Comparison of pharmacokinetic parameters of ranolazine between diabetic and non-diabetic rats [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Objective(s): Diabetes mellitus (DM) affects the pharmacokinetics of drugs. Ranolazine is an antianginal drug that is prescribed in DM patients with angina.
Habibeh Mashayekhi-sardoo, Hossein Kamali, Soghra Mehri, Amirhossein Sahebkar, Mohsen Imenshahidi, Amir Hooshang Mohammadpour   +5 more
doaj   +1 more source

Voriconazole Pharmacokinetics Are Not Altered in Critically Ill Patients with Acute-on-Chronic Liver Failure and Continuous Renal Replacement Therapy: An Observational Study

Microorganisms, 2021
Infection and sepsis are a main cause of acute-on-chronic liver failure (ACLF). Besides bacteria, molds play a role. Voriconazole (VRC) is recommended but its pharmacokinetics (PK) may be altered by ACLF.
Jörn Grensemann, Christoph Pfaffendorf, Sebastian G. Wicha, Christina König, Kevin Roedl, Dominik Jarczak, Stefanie Iwersen-Bergmann, Carolin Manthey, Stefan Kluge, Valentin Fuhrmann   +9 more
doaj   +1 more source

Probability distributions of landslide volumes [PDF]

Nonlinear Processes in Geophysics, 2009
Abstract. We examine 19 datasets with measurements of landslide volume, VL, for sub-aerial, submarine, and extraterrestrial mass movements. Individual datasets include from 17 to 1019 landslides of different types, including rock fall, rock slide, rock avalanche, soil slide, slide, and debris flow, with individual landslide volumes ranging over 10−4 m3≤
Brunetti MT, Guzzetti F, Rossi M
openaire   +6 more sources