Results 1 to 10 of about 6,046,760 (380)
Predicting Volume of Distribution in Neonates: Performance of Physiologically Based Pharmacokinetic Modelling [PDF]
Pharmaceutics, 2023 The volume of distribution at steady state (Vss) in neonates is still often estimated through isometric scaling from adult values, disregarding developmental changes beyond body weight.
Pieter-Jan De Sutter +4 more
doaj +2 more sources
Translational and Clinical Pharmacology, 2016 Nick Holford* and Dong-Seok Yim Department of Pharmacology & Clinical Pharmacology, University of Auckland, Auckland, New Zealand, Department of Clinical Pharmacology and Therapeutics, Seoul St.
Nick Holford, Dong-Seok Yim
openaire +2 more sources
QSAR Models for Predicting Oral Bioavailability and Volume of Distribution and Their Application in Mapping the TK Space of Endocrine Disruptors [PDF]
Journal of XenobioticsToxicokinetic (TK) properties are essential in the framework of chemical risk assessment and drug discovery. Specifically, a TK profile provides information about the fate of chemicals in the human body.
Guillaume Ollitrault +5 more
doaj +2 more sources
Interdisciplinary Collaboration on Real World Data to Close the Knowledge Gap: A Reflection on “De Sutter et al. Predicting Volume of Distribution in Neonates: Performance of Physiologically Based Pharmacokinetic Modelling” [PDF]
PharmaceuticsThis commentary further reflects on the paper of De Sutter et al. on predicting volume of distribution in neonates, and the performance of physiologically based pharmacokinetic models We hereby stressed the add on value to collaborate on real world data ...
Karel Allegaert +2 more
doaj +2 more sources
Journal of Pharmacy & Pharmaceutical Sciences, 2015 Purpose. The early prediction of pharmacokinetic behavior is of paramount importance for saving time and resources and for increasing the success of new drug candidates.
Zvetanka Dobreva Zhivkova +2 more
doaj +2 more sources
Methods to Predict Volume of Distribution. [PDF]
Curr Pharmacol Rep, 2019 Prior to human studies, knowledge of drug disposition in the body is useful to inform decisions on drug safety and efficacy, first in human dosing, and dosing regimen design. It is therefore of interest to develop predictive models for primary pharmacokinetic parameters, clearance, and volume of distribution.
Holt K, Nagar S, Korzekwa K.
europepmc +4 more sources
Citation: 'volume of distribution' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.12738 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms ...
Mansoor A, Mahabadi N.
europepmc +2 more sources
Volume and distribution of white matter hyperintensities in rheumatoid arthritis and ulcerative colitis patients. [PDF]
Sci RepCox JG +4 more
europepmc +3 more sources