Predicting Volume of Distribution in Neonates: Performance of Physiologically Based Pharmacokinetic Modelling [PDF]
Pharmaceutics, 2023 The volume of distribution at steady state (Vss) in neonates is still often estimated through isometric scaling from adult values, disregarding developmental changes beyond body weight.
Pieter-Jan De Sutter +4 more
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Translational and Clinical Pharmacology, 2016 Nick Holford* and Dong-Seok Yim Department of Pharmacology & Clinical Pharmacology, University of Auckland, Auckland, New Zealand, Department of Clinical Pharmacology and Therapeutics, Seoul St.
Dong-Seok Yim, Nicholas H. G. Holford
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Interdisciplinary Collaboration on Real World Data to Close the Knowledge Gap: A Reflection on “De Sutter et al. Predicting Volume of Distribution in Neonates: Performance of Physiologically Based Pharmacokinetic Modelling” [PDF]
PharmaceuticsThis commentary further reflects on the paper of De Sutter et al. on predicting volume of distribution in neonates, and the performance of physiologically based pharmacokinetic models We hereby stressed the add on value to collaborate on real world data ...
Karel Allegaert +2 more
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Methods to Predict Volume of Distribution. [PDF]
Curr Pharmacol Rep, 2019 Prior to human studies, knowledge of drug disposition in the body is useful to inform decisions on drug safety and efficacy, first in human dosing, and dosing regimen design. It is therefore of interest to develop predictive models for primary pharmacokinetic parameters, clearance, and volume of distribution.
Holt K, Nagar S, Korzekwa K.
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The mechanism of the osmotic adjustment of body cells as determined in vivo by the volume of distribution of a large water load. [PDF]
Journal of Clinical Investigation, 1954 Since permeability of cell membranes to water has been clearly demonstrated, there are several theoretically possible responses of cells to dilution of the extracellular fluid.
A. Leaf +3 more
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Markedly increased volume of distribution of gadolinium in cardiac amyloidosis demonstrated by T1 mapping. [PDF]
J Magn Reson Imaging, 2013 To perform myocardial T1 mapping pre‐ and post‐gadolinium (Gd) administration and determine the volume of distribution of Gd (VdGd) in patients with cardiac amyloidosis to assess extracellular space expansion from amyloid protein deposition.
Brooks J, Kramer CM, Salerno M.
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Distribution of Citations in one Volume of a Journal [PDF]
Interdisciplinary Description of Complex Systems, 2013 Citations to published scientific articles are regularly collected and processed, bringing about the impact factor and a large number of other bibliometric indicators.
Antonio Protić +2 more
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Journal of Pharmacy & Pharmaceutical Sciences, 2015 Purpose. The early prediction of pharmacokinetic behavior is of paramount importance for saving time and resources and for increasing the success of new drug candidates.
Zvetanka Dobreva Zhivkova +2 more
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Effects of drug transporters on volume of distribution. [PDF]
AAPS J, 2009 Recently, drug transporters have emerged as significant modifiers of a patient’s pharmacokinetics. In cases where the functioning of drug transporters is altered, such as by drug-drug interactions, by genetic polymorphisms, or as evidenced in knockout ...
Grover A, Benet LZ.
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Applying linear and non-linear methods for parallel prediction of volume of distribution and fraction of unbound drug. [PDF]
PLoS ONE, 2013 Volume of distribution and fraction unbound are two key parameters in pharmacokinetics. The fraction unbound describes the portion of free drug in plasma that may extravasate, while volume of distribution describes the tissue access and binding of a drug.
Eva M del Amo +5 more
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